Regulated formation and selection of neuronal processes underlie directional guidance of neuronal migration
文献类型：期刊论文
| 作者 | Ward, ME ; Jiang, H ; Rao, Y |
| 刊名 | MOLECULAR AND CELLULAR NEUROSCIENCE
 |
| 出版日期 | 2005 |
| 卷号 | 30期号:3页码:378-387 |
| 关键词 | DEVELOPING CEREBRAL-CORTEX CEREBELLAR GRANULE CELLS CENTRAL-NERVOUS-SYSTEM ADULT MAMMALIAN BRAIN GROWTH CONES SUBVENTRICULAR ZONE OLFACTORY-BULB PRECURSORS RECEPTORS NETRIN-1 |
| ISSN号 | 1044-7431 |
| 通讯作者 | Rao, Y (reprint author), Northwestern Univ, Dept Neurol, Feinberg Sch Med, 303 E Chicago Ave,Ward 10-185, Chicago, IL 60611 USA,y-rao@northwestern.edu |
| 英文摘要 | Axon guidance and neuronal migration are critical features of neural development, and it is believed that extracellular gradients of secreted guidance cues play important roles in pathfinding. It has been well documented that the growth cones of extending axons respond to such extracellular gradients by growing toward or away from the source of the secreted cue via asymmetrical extension of a single growth cone. However, it is unclear whether migrating neurons change direction in response to guidance molecules using the same mode of turning as extending axons. In this study, we demonstrate that migrating neurons turn away from the chemorepellent Slit through repeated rounds of process extension and retraction and do not turn through the reorientation of a single growth cone. We further show that Slit increases the rate of somal process formation and that these processes form preferentially on the side of the cell body furthest away from the Slit source. In addition, Slit causes cell turning through asymmetric process selection. Finally, we show that multiple types of migrating neurons employ this mode of cell turning in response to a variety of guidance cues. These results show that migrating neurons employ a unique type of turning when faced with secreted guidance cues that is distinct from the type employed by axons. (c) 2005 Elsevier Inc. All rights reserved. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1874]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Ward, ME,Jiang, H,Rao, Y. Regulated formation and selection of neuronal processes underlie directional guidance of neuronal migration[J]. MOLECULAR AND CELLULAR NEUROSCIENCE,2005,30(3):378-387. |
| APA | Ward, ME,Jiang, H,&Rao, Y.(2005).Regulated formation and selection of neuronal processes underlie directional guidance of neuronal migration.MOLECULAR AND CELLULAR NEUROSCIENCE,30(3),378-387. |
| MLA | Ward, ME,et al."Regulated formation and selection of neuronal processes underlie directional guidance of neuronal migration".MOLECULAR AND CELLULAR NEUROSCIENCE 30.3(2005):378-387. |
入库方式： OAI收割
来源：上海神经科学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。