Generation and characterization of the PKC gamma-Cre mouse line
文献类型：期刊论文
| 作者 | Ding, YQ ; Xiang, CX ; Chen, ZF |
| 刊名 | GENESIS
 |
| 出版日期 | 2005 |
| 卷号 | 43期号:1页码:28-33 |
| 关键词 | PKC gamma gene targeting Cre brain spinal cord PROTEIN-KINASE-C PERSISTENT PAIN SPINAL-CORD EXPRESSION MICE RESPONSES |
| ISSN号 | 1526-954X |
| 通讯作者 | Chen, ZF (reprint author), Washington Univ, Pain Ctr, Sch Med, Dept Anesthesiol, St Louis, MO 63110 USA,chenz@wustl.edu |
| 英文摘要 | PKC gamma is a protein kinase C (PKC) isoform that is expressed in the central nervous system (CNS). We generated a PKC gamma-Cre mouse line and characterized the expression and activity of the Cre protein. Our studies show that Cre expression largely recapitulates the endogenous expression of PKC gamma. Several major sites of Cre expression are the cerebral cortex, hippocampus, thalamus, amygdala, and spinal cord. Examination of PKC gamma-Cre/ROSA26 mice reveals a similar X-gal staining pattern in the CNS, indicating that Cre recombinase is capable of removing LoxP sites in vivo. These data indicate that the PKC gamma-Cre mouse line could be a useful reagent for generating Cre-mediated tissue-specific knockouts in the CNS. |
| 学科主题 | Developmental Biology ; Genetics & Heredity |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1883]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Ding, YQ,Xiang, CX,Chen, ZF. Generation and characterization of the PKC gamma-Cre mouse line[J]. GENESIS,2005,43(1):28-33. |
| APA | Ding, YQ,Xiang, CX,&Chen, ZF.(2005).Generation and characterization of the PKC gamma-Cre mouse line.GENESIS,43(1),28-33. |
| MLA | Ding, YQ,et al."Generation and characterization of the PKC gamma-Cre mouse line".GENESIS 43.1(2005):28-33. |
入库方式： OAI收割
来源：上海神经科学研究所
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