Activation of GPCRs modulates quantal size in chromaffin cells through G(beta gamma) and PKC
文献类型：期刊论文
| 作者 | Chen, XK ; Wang, LC ; Zhou, Y ; Cai, Q ; Prakriya, M ; Duan, KL ; Sheng, ZH ; Lingle, C ; Zhou, Z |
| 刊名 | NATURE NEUROSCIENCE
 |
| 出版日期 | 2005 |
| 卷号 | 8期号:9页码:1160-1168 |
| 关键词 | PROTEIN-KINASE-C FUSION PORE KINETICS BETA-GAMMA-SUBUNITS TRANSMITTER RELEASE NEUROTRANSMITTER RELEASE PRESYNAPTIC INHIBITION SECRETORY GRANULES VESICLE FUSION EXOCYTOSIS RECEPTOR |
| ISSN号 | 1097-6256 |
| 通讯作者 | Zhou, Z (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China,zzhou@pku.edu.cn |
| 英文摘要 | Exocytosis proceeds by either full fusion or 'kiss-and-run' between vesicle and plasma membrane. Switching between these two modes permits the cell to regulate the kinetics and amount of secretion. Here we show that ATP receptor activation reduces secretion downstream from cytosolic Ca2+ elevation in rat adrenal chromaffin cells. This reduction is mediated by activation of a pertussis toxin - sensitive G(i/o) protein, leading to activation of G(beta gamma) subunits, which promote the `kiss-and-run' mode by reducing the total open time of the fusion pore during a vesicle fusion event. Furthermore, parallel activation of the muscarinic acetylcholine receptor removes the inhibitory effects of ATP on secretion. This is mediated by a G(q) pathway through protein kinase C activation. The inhibitory effects of ATP and its reversal by protein kinase C activation are also shared by opioids and somatostatin. Thus, a variety of G protein pathways exist to modulate Ca2+-evoked secretion at specific steps in fusion pore formation. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1887]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Chen, XK,Wang, LC,Zhou, Y,et al. Activation of GPCRs modulates quantal size in chromaffin cells through G(beta gamma) and PKC[J]. NATURE NEUROSCIENCE,2005,8(9):1160-1168. |
| APA | Chen, XK.,Wang, LC.,Zhou, Y.,Cai, Q.,Prakriya, M.,...&Zhou, Z.(2005).Activation of GPCRs modulates quantal size in chromaffin cells through G(beta gamma) and PKC.NATURE NEUROSCIENCE,8(9),1160-1168. |
| MLA | Chen, XK,et al."Activation of GPCRs modulates quantal size in chromaffin cells through G(beta gamma) and PKC".NATURE NEUROSCIENCE 8.9(2005):1160-1168. |
入库方式： OAI收割
来源：上海神经科学研究所
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