Ca2+ sparks and secretion in dorsal root ganglion neurons
文献类型：期刊论文
| 作者 | Ouyang, KF ; Zheng, H ; Qin, XM ; Zhang, C ; Yang, DM ; Wang, X ; Wu, CH ; Zhou, Z ; Cheng, HP |
| 刊名 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
 |
| 出版日期 | 2005 |
| 卷号 | 102期号:34页码:12259-12264 |
| 关键词 | endoplasmic reticulum ryanodine receptor exocytosis RAT SENSORY NEURONS INDUCED CALCIUM-RELEASE SKELETAL-MUSCLE RYANODINE RECEPTORS TRANSMITTER RELEASE CELLS EXOCYTOSIS AMPLITUDE VOLTAGE TERMINATION |
| ISSN号 | 0027-8424 |
| 通讯作者 | Zhou, Z (reprint author), Peking Univ, Inst Mol Med, Beijing 100871, Peoples R China,zzhou@pku.edu.cn ; chengp@grc.nia.nih.gov |
| 英文摘要 | Ca2+ sparks as the elementary intracellular Ca2+ release events are instrumental to local control of Ca2+ signaling in many types of cells. Here, we visualized neural Ca2+ sparks in dorsal root ganglion (DRG) sensory neurons and investigated possible role of DRG sparks in the regulation of secretion from the somata of the cell. DRG sparks arose mainly from type 3 ryanodine receptor Ca2+ release channels on subsurface cisternae of the endoplasmic reticulum, rendering a striking subsurface localization. Caffeine- or 3,7-dimethyl-1-(2-propynyl)xanthine-induced store Ca2+ release, in the form of Ca2+ sparks, triggered exocytosis, independently of membrane depolarization and external Ca2+. The spark-secretion coupling probability was estimated to be between 1 vesicle per 6.6 sparks and 1 vesicle per 11.4 sparks. During excitation, subsurface sparks were evoked by physiological Ca2+ entry via the Ca2+- induced Ca2+ release mechanism, and their synergistic interaction with Ca2+ influx accounted for approximate to 60% of the Ca2+-dependent exocytosis. Furthermore, inhibition of Ca2+-induced Ca2+ release abolished endotoxin-induced secretion of pain-related neuropeptides. These findings underscore an important role for Ca2+ sparks in the amplification of surface Ca2+ influx and regulation of neural secretion. |
| 学科主题 | Science & Technology - Other Topics |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1889]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Ouyang, KF,Zheng, H,Qin, XM,et al. Ca2+ sparks and secretion in dorsal root ganglion neurons[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2005,102(34):12259-12264. |
| APA | Ouyang, KF.,Zheng, H.,Qin, XM.,Zhang, C.,Yang, DM.,...&Cheng, HP.(2005).Ca2+ sparks and secretion in dorsal root ganglion neurons.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,102(34),12259-12264. |
| MLA | Ouyang, KF,et al."Ca2+ sparks and secretion in dorsal root ganglion neurons".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102.34(2005):12259-12264. |
入库方式： OAI收割
来源：上海神经科学研究所
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