Long-term depression in rat CA1-subicular synapses depends on the G-protein coupled mACh receptors
文献类型：期刊论文
| 作者 | Li, HB ; Zhang, JC ; Xiong, WY ; Xu, TL(徐天乐) ; Cao, J ; Xu, L |
| 刊名 | NEUROSCIENCE RESEARCH
 |
| 出版日期 | 2005 |
| 卷号 | 52期号:3页码:287-294 |
| 关键词 | long-term depression (LTD) subiculum muscarinic receptor G-protein calcium HIPPOCAMPAL PYRAMIDAL CELLS SYNAPTIC PLASTICITY CA1 REGION ALZHEIMERS-DISEASE IN-VITRO AREA CA1 MEMORY POTENTIATION ACETYLCHOLINE NEURONS |
| ISSN号 | 0168-0102 |
| 通讯作者 | Cao, J (reprint author), Chinese Acad Sci, Kunming Inst Zool, Lab Learning & Memory, Kunming 650223, Peoples R China,juncao@vip.163.com |
| 英文摘要 | The subiculum, which is the primary target of CA1 pyramidal neurons and sending efferent fibres to many brain regions, serves as a hippocampal interface in the neural information processes between hippocampal formation and neocortex. Long-term depression (LTD) is extensively studied in the hippocampus, but not at the CA1-subicular synaptic transmission. Using whole-cell EPSC recordings in the brain slices of young rats, we demonstrated that the pairing protocols of low frequency stimulation (LFS) at 3 Hz and postsynaptic depolarization of -50 mVelicited a reliable LTD in the subiculum. The LTD did not cause the changes of the paired-pulse ratio of EPSC. Furthermore, it did not depend on either NMDA receptors or voltage-gated calcium channels (VGCCs). Bath application of the G-protein coupled muscarinic acetylcholine receptors (mAChRs) antagonists, atropine or scopolamine, blocked the LTD, suggesting that mAChRs are involved in the LTD. It was also completely blocked by either the Ca2+ chelator BAPTA or the G-protein inhibitor GDP-beta-S in the intracellular solution. This type of LTD in the subiculum may play a particular role in the neural information processing between the hippocampus and neocortex. (c) 2005 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1896]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Li, HB,Zhang, JC,Xiong, WY,et al. Long-term depression in rat CA1-subicular synapses depends on the G-protein coupled mACh receptors[J]. NEUROSCIENCE RESEARCH,2005,52(3):287-294. |
| APA | Li, HB,Zhang, JC,Xiong, WY,Xu, TL,Cao, J,&Xu, L.(2005).Long-term depression in rat CA1-subicular synapses depends on the G-protein coupled mACh receptors.NEUROSCIENCE RESEARCH,52(3),287-294. |
| MLA | Li, HB,et al."Long-term depression in rat CA1-subicular synapses depends on the G-protein coupled mACh receptors".NEUROSCIENCE RESEARCH 52.3(2005):287-294. |
入库方式： OAI收割
来源：上海神经科学研究所
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