Sodium salicylate reduces gamma aminobutyric acid-induced current in rat spinal dorsal horn neurons
文献类型：期刊论文
| 作者 | Xu, H ; Gong, N ; Chen, L ; Xu, TL(徐天乐) |
| 刊名 | NEUROREPORT
 |
| 出版日期 | 2005 |
| 卷号 | 16期号:8页码:813-816 |
| 关键词 | gamma-aminobutyric acid type A receptor pain regulation spinal dorsal horn neurons sodium salicylate whole-cell patch-clamp ANTIINFLAMMATORY DRUGS INFERIOR COLLICULUS TINNITUS MECHANISM MODEL PAIN |
| ISSN号 | 0959-4965 |
| 通讯作者 | Xu, TL (reprint author), Chinese Acad Sci, Inst Neurosci, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China,tlxu@ion.ac.cn |
| 英文摘要 | Sodium salicylate is one of the nonsteroidal antiinflammatory drugs and is clinically used for antiinflammation and chronic pain relief. In the present study, we investigated the actions of sodium salicylate on gamma-aminobutyric acid type A receptor (GABAA) current in cultured rat spinal dorsal horn neurons. Sodium salicylate was found to reduce GABAA current in a reversible and concentration-dependent manner, but did not change its ion selectivity. Sodium salicylate was effective only when GABA and sodium salicylate were applied together. Application of sodium salicylate immediately before, but not during, the application of GABA did not result in a significant reduction of GABAA current. Our results demonstrate that sodium salicylate reversibly attenuates the GABAA response of dorsal horn neurons, suggesting that GABAA receptors in the region are pharmacological targets of sodium salicylate. NeuroReport 16:813-816 (c) 2005 Lippincott Williams & Wilkins. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1902]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Xu, H,Gong, N,Chen, L,et al. Sodium salicylate reduces gamma aminobutyric acid-induced current in rat spinal dorsal horn neurons[J]. NEUROREPORT,2005,16(8):813-816. |
| APA | Xu, H,Gong, N,Chen, L,&Xu, TL.(2005).Sodium salicylate reduces gamma aminobutyric acid-induced current in rat spinal dorsal horn neurons.NEUROREPORT,16(8),813-816. |
| MLA | Xu, H,et al."Sodium salicylate reduces gamma aminobutyric acid-induced current in rat spinal dorsal horn neurons".NEUROREPORT 16.8(2005):813-816. |
入库方式： OAI收割
来源：上海神经科学研究所
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