Impairment of redox state and dopamine level induced by alpha-synuclein aggregation and the preventive effect of hsp70
文献类型：期刊论文
| 作者 | Yu, FR ; Xu, HT ; Zhuo, M ; Sun, LY ; Dong, AW ; Liu, XY |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2005 |
| 卷号 | 331期号:1页码:278-284 |
| ISSN号 | 0006-291X |
| 关键词 | dopamine Lewy body neurodegeneration oxidative stress Parkinson's disease SK-N-SII cell line PARKINSONS-DISEASE DROSOPHILA MODEL 6-HYDROXYDOPAMINE DEGENERATION SUPPRESSION RAT |
| 通讯作者 | Liu, XY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,xyliu@sibs.ac.cn |
| 英文摘要 | One hypothesis for the etiology of Parkinson's disease (PD) is that the formation of' proteinaceous inclusion, which is mainly composed of α-synuclein, may contribute to the selective loss of dopaminergic neurons, To further explore the role of α-synuclein in neurodegeneration of PD, we examined the possible effects of aggregated α-synuclein on the intracellular redox state, dopamine level, and cell death of SK-N-SH cells. Our present Studies show that α-synuclein aggregation gives rise to both elevated intracellular oxidative state and dopamine level in SK-N-SH cells. Moreover, α-synuclein aggregation results in a higher ratio of apoptosis population (55.8% ± SEM) in cells overexpressing α-synuclein aggregation. compared to their normal Control groups (8,0% + SEM), In contrast. coexpression of hsp70 with α-synuclein suppresses the oxidative state shift. restores the normal dopamine levels and blocks neuron cell loss. Therefore, our data provided one possible mechanism by which the α-synuclein aggregation may lead to the neurodegeneration in PD via regulating the level of cytoplasmic dopamine and then disturbing, the intracellular redox homeostasis. On the other hand, hsp70 can mitigate the degenerative effect conferred by α-synuclein, acting as a protective factor in treatment or PD. © 2005 Elsevier Inc. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology ; Biophysics |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1904]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Yu, FR,Xu, HT,Zhuo, M,et al. Impairment of redox state and dopamine level induced by alpha-synuclein aggregation and the preventive effect of hsp70[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2005,331(1):278-284. |
| APA | Yu, FR,Xu, HT,Zhuo, M,Sun, LY,Dong, AW,&Liu, XY.(2005).Impairment of redox state and dopamine level induced by alpha-synuclein aggregation and the preventive effect of hsp70.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,331(1),278-284. |
| MLA | Yu, FR,et al."Impairment of redox state and dopamine level induced by alpha-synuclein aggregation and the preventive effect of hsp70".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 331.1(2005):278-284. |
入库方式： OAI收割
来源：上海神经科学研究所
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