Essential role of TRPC channels in the guidance of nerve growth cones by brain-derived neurotrophic factor
文献类型：期刊论文
| 作者 | Li, Y ; Jia, YC ; Cui, K ; Li, N ; Zheng, ZY ; Wang, YZ ; Yuan, XB |
| 刊名 | NATURE
 |
| 出版日期 | 2005 |
| 卷号 | 434期号:7035页码:894-898 |
| 关键词 | PHOSPHOLIPASE-C CATION CHANNELS AXON GUIDANCE CELLS RECEPTORS ACTIVATION INHIBITOR CURRENTS FAMILY BDNF |
| ISSN号 | 0028-0836 |
| 通讯作者 | Yuan, XB (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China,yzwang@ion.ac.cn ; yuanxb@ion.ac.cn |
| 英文摘要 | Brain-derived neurotrophic factor ( BDNF) is known to promote neuronal survival and differentiation(1) and to guide axon extension both in vitro(2,3) and in vivo(4). The BDNF-induced chemoattraction of axonal growth cones requires Ca2+ signalling(3), but how Ca2+ is regulated by BDNF at the growth cone remains largely unclear. Extracellular application of BDNF triggers membrane currents resembling those through TRPC ( transient receptor potential canonical) channels in rat pontine neurons(5) and in Xenopus spinal neurons(6). Here, we report that in cultured cerebellar granule cells, TRPC channels contribute to the BDNF-induced elevation of Ca2+ at the growth cone and are required for BDNF-induced chemo-attractive turning. Several members of the TRPC family are highly expressed in these neurons, and both Ca2+ elevation and growth-cone turning induced by BDNF are abolished by pharmacological inhibition of TRPC channels, overexpression of a dominant-negative form of TRPC3 or TRPC6, or downregulation of TRPC3 expression via short interfering RNA. Thus, TRPC channel activity is essential for nerve-growth-cone guidance by BDNF. |
| 学科主题 | Science & Technology - Other Topics |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1911]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Li, Y,Jia, YC,Cui, K,et al. Essential role of TRPC channels in the guidance of nerve growth cones by brain-derived neurotrophic factor[J]. NATURE,2005,434(7035):894-898. |
| APA | Li, Y.,Jia, YC.,Cui, K.,Li, N.,Zheng, ZY.,...&Yuan, XB.(2005).Essential role of TRPC channels in the guidance of nerve growth cones by brain-derived neurotrophic factor.NATURE,434(7035),894-898. |
| MLA | Li, Y,et al."Essential role of TRPC channels in the guidance of nerve growth cones by brain-derived neurotrophic factor".NATURE 434.7035(2005):894-898. |
入库方式： OAI收割
来源：上海神经科学研究所
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