Cyclic AMP controls BDNF-induced TrkB phosphorylation and dendritic spine formation in mature hippocampal neurons
文献类型：期刊论文
| 作者 | Ji, YY ; Pang, PT ; Feng, LY ; Lu, B |
| 刊名 | NATURE NEUROSCIENCE
 |
| 出版日期 | 2005 |
| 卷号 | 8期号:2页码:164-172 |
| 关键词 | NEUROTROPHIC FACTOR EXCITATORY SYNAPSES POSTSYNAPTIC DENSITIES SYNAPTIC-TRANSMISSION SURFACE EXPRESSION PRIMARY CULTURES FULL-LENGTH CAMP POTENTIATION RELEASE |
| ISSN号 | 1097-6256 |
| 通讯作者 | Lu, B (reprint author), NICHHD, NIH, Sect Neural Dev & Plast, 35 Lincoln Dr, Bethesda, MD 20892 USA,bailu@mail.nih.gov |
| 英文摘要 | Synaptic actions of brain-derived neurotrophic factor (BDNF) are 'gated' by cyclic AMP (cAMP), but the underlying molecular mechanisms remain unclear. Here we report that cAMP regulates BDNF function in mature hippocampal neurons by modulating the signaling and trafficking of its receptor TrkB. cAMP gated the TrkB tyrosine kinase with three characteristic features: BDNF-induced TrkB phosphorylation was attenuated by inhibitors of cAMP signaling, it was potentiated by cAMP analogs, and activation of the cAMP pathway alone had no effect. In addition, cAMP facilitated trafficking of TrkB to dendritic spines, possibly by promoting its interaction with synaptic scaffolding protein PSD-95. Norepinephrinergic and dopaminergic agonists, which elevate intracellular cAMP concentration, also enhanced TrkB phosphorylation and its translocation to spines. cAMP gated long-term modulation by BDNF of spine density, but not the number of primary dendrites. These results reveal a specific role of cAMP in controlling BDNF actions in the brain, and provide new insights into the molecular mechanism underlying cAMP gating. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1922]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Ji, YY,Pang, PT,Feng, LY,et al. Cyclic AMP controls BDNF-induced TrkB phosphorylation and dendritic spine formation in mature hippocampal neurons[J]. NATURE NEUROSCIENCE,2005,8(2):164-172. |
| APA | Ji, YY,Pang, PT,Feng, LY,&Lu, B.(2005).Cyclic AMP controls BDNF-induced TrkB phosphorylation and dendritic spine formation in mature hippocampal neurons.NATURE NEUROSCIENCE,8(2),164-172. |
| MLA | Ji, YY,et al."Cyclic AMP controls BDNF-induced TrkB phosphorylation and dendritic spine formation in mature hippocampal neurons".NATURE NEUROSCIENCE 8.2(2005):164-172. |
入库方式： OAI收割
来源：上海神经科学研究所
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