Both the establishment and the maintenance of neuronal polarity require active mechanisms: Critical roles of GSK-3 beta and its upstream regulators
文献类型：期刊论文
| 作者 | Jiang, H ; Guo, W ; Liang, XH ; Rao, Y |
| 刊名 | CELL
 |
| 出版日期 | 2005 |
| 卷号 | 120期号:1页码:123-135 |
| 关键词 | GLYCOGEN-SYNTHASE KINASE-3 CULTURED HIPPOCAMPAL-NEURONS DISPERSED CELL-CULTURE PROTEIN-KINASE GROWTH CONES TUMOR-SUPPRESSOR AXON FORMATION PHOSPHORYLATION INHIBITION TAU |
| ISSN号 | 0092-8674 |
| 通讯作者 | Rao, Y (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Grad Sch, 320 Yueyang Rd, Shanghai 200031, Peoples R China,y-rao@northwestem.edu |
| 英文摘要 | Axon-dendrite polarity is a cardinal feature of neuronal morphology essential for information flow. Here we report a differential distribution of GSK-3beta activity in the axon versus the dendrites. A constitutively active GSK-3beta mutant inhibited axon formation, whereas multiple axons formed from a single neuron when GSK-3beta activity was reduced by pharmacological inhibitors, a peptide inhibitor, or siRNAs. An active mechanism for maintaining neuronal polarity was revealed by the conversion of preexisting dendrites into axons upon GSK-3 inhibition. Biochemical and functional data show that the Akt kinase and the PTEN phosphatase are upstream of GSK-3beta in determining neuronal polarity. Our results demonstrate that there are active mechanisms for maintaining as well as establishing neuronal polarity, indicate that GSK-3beta relays signaling from Akt and PTEN to play critical roles in neuronal polarity, and suggest that application of GSK-3beta inhibitors can be a novel approach to promote generation of new axons after neural injuries. |
| 学科主题 | Biochemistry & Molecular Biology ; Cell Biology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1924]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Jiang, H,Guo, W,Liang, XH,et al. Both the establishment and the maintenance of neuronal polarity require active mechanisms: Critical roles of GSK-3 beta and its upstream regulators[J]. CELL,2005,120(1):123-135. |
| APA | Jiang, H,Guo, W,Liang, XH,&Rao, Y.(2005).Both the establishment and the maintenance of neuronal polarity require active mechanisms: Critical roles of GSK-3 beta and its upstream regulators.CELL,120(1),123-135. |
| MLA | Jiang, H,et al."Both the establishment and the maintenance of neuronal polarity require active mechanisms: Critical roles of GSK-3 beta and its upstream regulators".CELL 120.1(2005):123-135. |
入库方式： OAI收割
来源：上海神经科学研究所
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