Substance P promotes sleep in the ventrolateral preoptic area of rats
文献类型：期刊论文
| 作者 | Zhang, GL ; Wang, LC ; Liu, H ; Zhang, JX |
| 刊名 | BRAIN RESEARCH
 |
| 出版日期 | 2004 |
| 卷号 | 1028期号:2页码:225-232 |
| 关键词 | ventrolateral preoptic area polysomnography sleep slow wave sleep gamma-aminobutyric acid PHOSPHOLIPASE-C INHIBITOR CENTRAL-NERVOUS-SYSTEM HYPOTHALAMIC NEURONS BASAL FOREBRAIN GLUTAMATE DECARBOXYLASE AMINO-ACIDS REM-SLEEP NUCLEUS RECEPTOR LESIONS |
| ISSN号 | 0006-8993 |
| 通讯作者 | Zhang, JX (reprint author), Anhui Med Univ, Sleep Res Lab, Hefei 230022, Anhui, Peoples R China,jingxingz@yahoo.com.cn |
| 英文摘要 | Substance P (SP) has been characterized as an excitatory neurotransmitter and/or neuromodulator in the peripheral and central nervous systems. It is involved in mediating various biological functions such as smooth muscle contraction, neuronal excitation, and pain transmission. Although Lieb et al. reported that intravenous infusion of SP into healthy men led to an increase of paradoxical sleep latency and time awake, little is known about the function and target of SP on sleep-wakefulness cycle in the central nervous system. The ventrolateral preoptic area (vLPO) plays an important role in modulation of sleep-wakefulness cycle. The present study investigated the effect of SP on sleep-wakefulness cycle in the vLPO of rats. Slow wave sleep (SWS) was enhanced after SP was microinjected into bilateral vLPO, while SP receptor antagonist, Nacetyl-L-tryptophan 3,5-bis(trifluoromethyl)-benzyl ester, led to the opposite effect. The effect induced by SP was blocked by U73122, a phospholipase C inhibitor. In addition, 3-mercaptopropionic acid, a glutamic acid decarboxylase inhibitor that inhibits gamma-aminobutyric acid (GABA) synthesis and release, blocked the SP-induced sleep-promoting effect in the vLPO. These results indicate that SP has sleep-promoting effect in the vLPO possibly by GABAergic neurons. (C) 2004 Elsevier B.V. All rights reserved. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1930]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Zhang, GL,Wang, LC,Liu, H,et al. Substance P promotes sleep in the ventrolateral preoptic area of rats[J]. BRAIN RESEARCH,2004,1028(2):225-232. |
| APA | Zhang, GL,Wang, LC,Liu, H,&Zhang, JX.(2004).Substance P promotes sleep in the ventrolateral preoptic area of rats.BRAIN RESEARCH,1028(2),225-232. |
| MLA | Zhang, GL,et al."Substance P promotes sleep in the ventrolateral preoptic area of rats".BRAIN RESEARCH 1028.2(2004):225-232. |
入库方式： OAI收割
来源：上海神经科学研究所
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