Spontaneous waves in the ventricular zone of developing mammalian retina
文献类型：期刊论文
| 作者 | Syed, MM ; Lee, S ; He, SG ; Zhou, ZJ |
| 刊名 | JOURNAL OF NEUROPHYSIOLOGY
 |
| 出版日期 | 2004 |
| 卷号 | 91期号:5页码:1999-2009 |
| 关键词 | SPONTANEOUS CA2+ TRANSIENTS INNER PLEXIFORM LAYER DEVELOPING RAT RETINA NERVOUS-SYSTEM NEURONAL DIFFERENTIATION AMACRINE CELLS CHICK RETINA CIRCUITS TRANSMISSION PROPAGATION |
| ISSN号 | 0022-3077 |
| 通讯作者 | Zhou, ZJ (reprint author), Univ Arkansas Med Sci Hosp, Dept Physiol & Biophys, Mail Slot 505, Little Rock, AR 72205 USA,zhoujimmy@uams.edu |
| 英文摘要 | Spontaneous rhythmic waves in the developing mammalian retina are thought to propagate among differentiated neurons in the inner retina (IR) and play an important role in activity-dependent visual development. Here we report a new form of rhythmic Ca2+ wave in the ventricular zone (VZ) of the developing rabbit retina. Ca2+ imaging from two-photon optical sections near the ventricular surface of the whole-mount retina showed rhythmic Ca2+ transients propagating laterally as waves. The VZ waves had a distinctively slow Ca2+ dynamics (lasting similar to20 s) but shared a similar frequency and propagation speed with the IR waves. Simultaneous Ca2+ imaging in VZ and multi-electrode array recording in the ganglion cell layer (GCL) revealed close spatiotemporal correlation between spontaneous VZ and IR waves, suggesting a common source of initiation and/or regulation of the two waves. Pharmacological studies further showed that all drugs that blocked IR waves also blocked VZ waves. However, the muscarinic antagonist atropine selectively blocked VZ but not IR waves at this developmental stage, indicating that IR waves were not dependent on VZ waves, but VZ waves likely relied on the initiation of IR waves. Eliciting IR waves with puffs of nicotinic or non-N-methyl-D-aspartate agonists in GCL produced atropine-sensitive waves in the VZ, demonstrating a unique, retrograde signaling pathway from IR to VZ. Thus differentiated neurons in the IR use spontaneous, rhythmic waves to send both forward signals to the central visual targets and retrograde messages to the developing cells in the VZ. |
| 学科主题 | Neurosciences & Neurology ; Physiology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1961]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Syed, MM,Lee, S,He, SG,et al. Spontaneous waves in the ventricular zone of developing mammalian retina[J]. JOURNAL OF NEUROPHYSIOLOGY,2004,91(5):1999-2009. |
| APA | Syed, MM,Lee, S,He, SG,&Zhou, ZJ.(2004).Spontaneous waves in the ventricular zone of developing mammalian retina.JOURNAL OF NEUROPHYSIOLOGY,91(5),1999-2009. |
| MLA | Syed, MM,et al."Spontaneous waves in the ventricular zone of developing mammalian retina".JOURNAL OF NEUROPHYSIOLOGY 91.5(2004):1999-2009. |
入库方式： OAI收割
来源：上海神经科学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。