Ion channels mediate proton transduction in peripheral pain perception
文献类型：期刊论文
| 作者 | Wu, LJ ; Xu, TL(徐天乐) |
| 刊名 | PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
 |
| 出版日期 | 2004 |
| 卷号 | 31期号:5页码:393-397 |
| 关键词 | pain tissue acidosis ion channels CAPSAICIN RECEPTOR P2X RECEPTORS MICE LACKING K+ CHANNEL NEURONS RAT NOCICEPTION STIMULI FAMILY PH |
| ISSN号 | 1000-3282 |
| 其他题名 | 组织酸化参与外周痛觉传递的离子通道机制 |
| 通讯作者 | Xu, TL (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China,tlxu@ion.ac.cn |
| 英文摘要 | Tissue acidosis can directly induce pain sensation which is mediated by ion channels in peripheral sensory neurons. To date, several ion channel superfamilies are identified to be involved in the pain from tissue acidosis. ( 1) ASICs can be gated by proton and directly mediate the acidosis pain; (2) VR1 can be sensitized by acidosis as well as activated by pH < 6.0; (3) P2X2 receptor is up-modulated whereas P2X3 is down-modulated by acidosis; (4) TASK is one of the tandem pore and the inwardly rectifying K+ channel which can be closed by acidosis. |
| 学科主题 | Biochemistry & Molecular Biology ; Biophysics |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1963]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Wu, LJ,Xu, TL. Ion channels mediate proton transduction in peripheral pain perception[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2004,31(5):393-397. |
| APA | Wu, LJ,&Xu, TL.(2004).Ion channels mediate proton transduction in peripheral pain perception.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,31(5),393-397. |
| MLA | Wu, LJ,et al."Ion channels mediate proton transduction in peripheral pain perception".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 31.5(2004):393-397. |
入库方式： OAI收割
来源：上海神经科学研究所
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