The effect of acute stress on LTP and LTD induction in the hippocampal CA1 region of anesthetized rats at three different ages
文献类型：期刊论文
| 作者 | Xiong, WY ; Wei, HM ; Xiang, XJ ; Cao, J ; Dong, ZF ; Wang, YF ; Xu, TL(徐天乐) ; Xu, L |
| 刊名 | BRAIN RESEARCH
 |
| 出版日期 | 2004 |
| 卷号 | 1005期号:40910页码:187-192 |
| 关键词 | long-term potentiation long-term depression stress aberrant memory stress experience-dependent long-term depression (SLTD) LONG-TERM POTENTIATION SYNAPTIC PLASTICITY SPATIAL MEMORY IN-VIVO AREA CA1 GLUCOCORTICOID-RECEPTOR FREQUENCY STIMULATION RODENT HIPPOCAMPUS DEPRESSION EXPERIENCE |
| ISSN号 | 0006-8993 |
| 通讯作者 | Xu, L (reprint author), Chinese Acad Sci, Lab Learning & Memory, Kunming Inst Zool, 32 Jiaochang Donglu, Kunming 650223, Yunnan, Peoples R China,lxu@vip.163.com |
| 英文摘要 | Not all experiences are memorized equally well. Especially, some types of stress are unavoidable in daily life and the stress experience can be memorized for life. Previous evidence has showed that synaptic plasticity, such as long-term potentiation (LTP) that may be the major cellular model of the mechanism underlying learning and memory, is influenced by behavioral stress. However, the effect of behavioral stress on age-related synaptic plasticity in-vivo was primarily known. Here we found that the LTP induction in the hippocampal CA1 region of anesthetized rats obviously showed inverted-U shape related to ages (4, 10 and 74 weeks old rats), but low-frequency stimulation was unable to induce reliable long-term depression (LTD) in these animals. Furthermore, acute elevated platform (EP) stress enabled reliable LTD significantly and completely blocked LTP induction at these ages. Importantly, LTD after exposure to acute EP stress showed similar magnitude over these ages. The present results that stress enables LTD but impairs LTP induction at these three ages strengthen a view that stress experience-dependent LTD (SLTD) may underlie stress form of aberrant memories. (C) 2004 Elsevier B.V. All rights reserved. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1967]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Xiong, WY,Wei, HM,Xiang, XJ,et al. The effect of acute stress on LTP and LTD induction in the hippocampal CA1 region of anesthetized rats at three different ages[J]. BRAIN RESEARCH,2004,1005(40910):187-192. |
| APA | Xiong, WY.,Wei, HM.,Xiang, XJ.,Cao, J.,Dong, ZF.,...&Xu, L.(2004).The effect of acute stress on LTP and LTD induction in the hippocampal CA1 region of anesthetized rats at three different ages.BRAIN RESEARCH,1005(40910),187-192. |
| MLA | Xiong, WY,et al."The effect of acute stress on LTP and LTD induction in the hippocampal CA1 region of anesthetized rats at three different ages".BRAIN RESEARCH 1005.40910(2004):187-192. |
入库方式： OAI收割
来源：上海神经科学研究所
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