Calcium signaling in chemorepellant Slit2-dependent regulation of neuronal migration
文献类型：期刊论文
| 作者 | Xu, HT ; Yuan, XB ; Guan, CB ; Duan, SM ; Wu, CP ; Feng, LY |
| 刊名 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
 |
| 出版日期 | 2004 |
| 卷号 | 101期号:12页码:4296-4301 |
| 关键词 | NERVE GROWTH CONES INTRACELLULAR CA2+ FLUCTUATIONS TRANSIENTS GUIDANCE CELLS RECEPTORS SYSTEM MODULATION CHEMOTAXIS ACTIVATION |
| ISSN号 | 0027-8424 |
| 通讯作者 | Feng, LY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, 320 Yueyang Rd, Shanghai 200031, Peoples R China,lyfeng@ion.ac.cn |
| 英文摘要 | Migration of neuronal precursor cells in the developing brain is guided by extracellular cues, but intracellular signaling processes underlying the guidance of neuronal migration are largely unknown. By examining the migration of cerebellar granule neurons along the surface of cocultured astroglial cells, we found that an extracellular gradient of Slit2, a chemorepellant for neuronal migration in vivo, caused a reversal in the direction of migration without affecting the migration speed. A Slit2 gradient elevated the intracellular concentration of Ca2+, probably due to calcium release from the internal store, led to a reversal of the preexisting asymmetric intracellular Ca2+ distribution in the soma of migrating neurons, and this reversal was closely related with its action of reversing the migrating direction. Asymmetric Ca2+ distribution in the soma was both necessary and sufficient for directing neuronal migration. These results have demonstrated an important role for Ca2+ in mediating neuronal responses to Slit2 and suggest a general mechanism for neuronal guidance. |
| 学科主题 | Science & Technology - Other Topics |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1972]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Xu, HT,Yuan, XB,Guan, CB,et al. Calcium signaling in chemorepellant Slit2-dependent regulation of neuronal migration[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2004,101(12):4296-4301. |
| APA | Xu, HT,Yuan, XB,Guan, CB,Duan, SM,Wu, CP,&Feng, LY.(2004).Calcium signaling in chemorepellant Slit2-dependent regulation of neuronal migration.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,101(12),4296-4301. |
| MLA | Xu, HT,et al."Calcium signaling in chemorepellant Slit2-dependent regulation of neuronal migration".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101.12(2004):4296-4301. |
入库方式： OAI收割
来源：上海神经科学研究所
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