Implication of gamma-secretase in neuregulin-induced maturation of oligodendrocytes
文献类型：期刊论文
| 作者 | Lai, C ; Feng, LY |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2004 |
| 卷号 | 314期号:2页码:535-542 |
| 关键词 | ErbB4 neuregulin gamma-secretase nuclear translocation oligodendrocyte maturation myelination MYELINATING SCHWANN-CELLS YES-ASSOCIATED PROTEIN SIGNAL-TRANSDUCTION PRECURSOR CELLS TYROSINE KINASE DENTATE GYRUS GROWTH-FACTOR ADULT-RAT IN-VITRO PROLIFERATION |
| ISSN号 | 0006-291X |
| 通讯作者 | Feng, LY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China,lyfeng@sibs.ac.cn |
| 英文摘要 | Increasing evidences suggest that, after neuregulin (NRG) stimulation, ErbB34 undergoes a series of proteolysis, including gamma-secretase cleavage. The released ErbB4 intracellular domain (EICD) is translocated into nucleus and has a transcriptional function. Although NRG-ErbB4 signaling mediates maturation of oligodendrocytes (OLs), the role of EICD and gamma-secretase in this process remains elusive. Here, we showed that NRG-ErbB4 interaction accumulated EICD in the nucleus and promoted the expression of myelin basic protein expression in OLs. Conversely, inhibitor of ErbB34 or gamma-secretase blocked the capacity of NRG. Nuclear accumulation of EICD did not influence maturation of neurons and astrocytes and early development of OLs. We also found that EICD translocation accorded a temporal pattern, consistent with the developmental gradient of hippocampus. Our data suggest that gamma-secretase activation and EICD nuclear translocation are required for OL maturation induced by NRG, and ErbB4 acts as a functional receptor depending on a new signaling cascade. (C) 2003 Elsevier Inc. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology ; Biophysics |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1975]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Lai, C,Feng, LY. Implication of gamma-secretase in neuregulin-induced maturation of oligodendrocytes[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2004,314(2):535-542. |
| APA | Lai, C,&Feng, LY.(2004).Implication of gamma-secretase in neuregulin-induced maturation of oligodendrocytes.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,314(2),535-542. |
| MLA | Lai, C,et al."Implication of gamma-secretase in neuregulin-induced maturation of oligodendrocytes".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 314.2(2004):535-542. |
入库方式： OAI收割
来源：上海神经科学研究所
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