Regulation of TrkB receptor tyrosine kinase and its internalization by neuronal activity and Ca2+ influx
文献类型：期刊论文
| 作者 | Du, J ; Feng, LY ; Zaitsev, E ; Je, HS ; Liu, XW ; Lu, B |
| 刊名 | JOURNAL OF CELL BIOLOGY
 |
| 出版日期 | 2003 |
| 卷号 | 163期号:2页码:385-395 |
| 关键词 | BDNF endocytosis calcium influx hippocampus activity dependent NERVE GROWTH-FACTOR DEVELOPING NEUROMUSCULAR SYNAPSES NEUROTROPHIN SIGNAL-TRANSDUCTION HIPPOCAMPAL-NEURONS SYMPATHETIC NEURONS RETROGRADE SIGNAL PLASMA-MEMBRANE POTENTIATION ENDOCYTOSIS CLATHRIN |
| ISSN号 | 0021-9525 |
| 通讯作者 | Lu, B (reprint author), NICHD, Sect Neural Dev & Plast, Lab Cellular & Synapt Neurophysiol, NIH, Bldg 49,Rm 6A80,49 Convent Dr, Bethesda, MD 20892 USA, |
| 英文摘要 | Internalization of the neurotrophin-Trk receptor complex is critical for many aspects of neurotrophin functions. The mechanisms governing the internalization process are unknown. Here, we report that neuronal activity facilitates the internalization of the receptor for brain-derived neurotrophic factor, TrkB, by potentiating its tyrosine kinase activity. Using three independent approaches, we show that electric stimulation of hippocampal neurons markedly enhances TrkB internalization. Electric stimulation also potentiates TrkB tyrosine kinase activity. The activity-dependent enhancement of TrkB internalization and its tyrosine kinase requires Ca2+ influx through N-methyl-D-aspartate receptors and Ca2+ channels. inhibition of internalization had no effect on TrkB kinase, but inhibition of TrkB kinase prevents the modulation of TrkB internalization, suggesting a critical role of the tyrosine kinase in the activity-dependent receptor endocytosis. These results demonstrate an activity and Ca2+-dependent modulation of TrkB tyrosine kinase and its internalization, and they provide new insights into the cell biology of tyrosine kinase receptors. |
| 学科主题 | Cell Biology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1996]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Du, J,Feng, LY,Zaitsev, E,et al. Regulation of TrkB receptor tyrosine kinase and its internalization by neuronal activity and Ca2+ influx[J]. JOURNAL OF CELL BIOLOGY,2003,163(2):385-395. |
| APA | Du, J,Feng, LY,Zaitsev, E,Je, HS,Liu, XW,&Lu, B.(2003).Regulation of TrkB receptor tyrosine kinase and its internalization by neuronal activity and Ca2+ influx.JOURNAL OF CELL BIOLOGY,163(2),385-395. |
| MLA | Du, J,et al."Regulation of TrkB receptor tyrosine kinase and its internalization by neuronal activity and Ca2+ influx".JOURNAL OF CELL BIOLOGY 163.2(2003):385-395. |
入库方式： OAI收割
来源：上海神经科学研究所
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