Inhibition of glycine response by amiloride in rat spinal neurons
文献类型：期刊论文
| 作者 | Li, YF ; Li, Y ; Xu, TL(徐天乐) |
| 刊名 | NEUROSCIENCE LETTERS
 |
| 出版日期 | 2003 |
| 卷号 | 345期号:3页码:173-176 |
| 关键词 | amiloride glycine receptor GABA(A) receptor Cl- channel interaction spinal dorsal horn neurons DORSAL COMMISSURAL NEURONS NA+ CHANNEL RECEPTORS ANALOGS TRANSPORT TOOLS BRAIN |
| ISSN号 | 0304-3940 |
| 通讯作者 | Xu, TL (reprint author), Univ Sci & Technol, Dept Neurobiol & Biophys, Hefei 230027, Peoples R China, |
| 英文摘要 | The modulatory effect of amiloride on glycine-activated current (I-Gly) was investigated in acutely dissociated rat spinal dorsal horn neurons using the whole-cell patch clamp technique. Amiloride inhibited I-Gly reversibly in a concentration-dependent manner. It shifted the concentration-response relationship to the right without altering the maximum response and Hill coefficient of the I-Gly. Amiloride did not change the ion selectivity of glycine receptor either. In addition, Na+- or Ca2+-free extracellular solutions and intracellular application of amiloride did not alter the amiloride inhibition of I-Gly. These results indicate that amiloride directly inhibited the glycine receptor response by decreasing the affinity of glycine to its receptor. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2013]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Li, YF,Li, Y,Xu, TL. Inhibition of glycine response by amiloride in rat spinal neurons[J]. NEUROSCIENCE LETTERS,2003,345(3):173-176. |
| APA | Li, YF,Li, Y,&Xu, TL.(2003).Inhibition of glycine response by amiloride in rat spinal neurons.NEUROSCIENCE LETTERS,345(3),173-176. |
| MLA | Li, YF,et al."Inhibition of glycine response by amiloride in rat spinal neurons".NEUROSCIENCE LETTERS 345.3(2003):173-176. |
入库方式： OAI收割
来源：上海神经科学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。