Ligand-dependent recruitment of the ErbB4 signaling complex into neuronal lipid rafts
文献类型：期刊论文
| 作者 | Ma, L ; Huang, YZ ; Pitcher, GM ; Valtschanoff, JG ; Ma, YH ; Feng, LY ; Lu, B ; Xiong, WC ; Salter, MW ; Weinberg, RJ ; Mei, L |
| 刊名 | JOURNAL OF NEUROSCIENCE
 |
| 出版日期 | 2003 |
| 卷号 | 23期号:8页码:3164-3175 |
| 关键词 | lipid rafts ErbB4 NRG PSD-95 postsynaptic density long-term potentiation synaptic plasticity RECEPTOR GENE-EXPRESSION SOMATIC SENSORY CORTEX LONG-TERM POTENTIATION NERVOUS-SYSTEM POSTSYNAPTIC DENSITY NEUREGULIN RECEPTOR NEUROMUSCULAR-JUNCTION TRANSMEMBRANE DOMAIN HIPPOCAMPAL-NEURONS CONTAINING PROTEINS |
| ISSN号 | 0270-6474 |
| 通讯作者 | Mei, L (reprint author), Univ Alabama, Sch Med, Dept Neurobiol, Civitan Int Res Ctr 516, 1719 6th Ave S, Birmingham, AL 35294 USA, |
| 英文摘要 | Neuregulin (NRG) regulates synapse formation and synaptic plasticity, but little is known about the regulation of NRG signaling at synapses. Here we show that the NRG receptor ErbB4 was localized in anatomically defined postsynaptic densities in the brain. In cultured cortical neurons, ErbB4 was recruited to the neuronal lipid raft fraction after stimulation by NRG. Along with ErbB4, adaptor proteins Grb2 and Shc were translocated to lipid rafts by NRG stimulation. In transfected human embryonic kidney 293 cells, the partitioning of ErbB4 into a detergent-insoluble fraction that includes lipid rafts was increased by PSD-95 ( postsynaptic density-95), through interaction of the ErbB4 C terminus with the PDZ [PSD-95/Discs large/zona occludens-1] domains of PSD-95. Disruption of lipid rafts inhibited NRG-induced activation of Erk and prevented NRG-induced blockade of induction of long-term potentiation at hippocampal CA1 synapses. Thus, our results indicate that NRG stimulation causes translocation of ErbB4 into lipid rafts and that lipid rafts are necessary for signaling by ErbB4. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2021]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Ma, L,Huang, YZ,Pitcher, GM,et al. Ligand-dependent recruitment of the ErbB4 signaling complex into neuronal lipid rafts[J]. JOURNAL OF NEUROSCIENCE,2003,23(8):3164-3175. |
| APA | Ma, L.,Huang, YZ.,Pitcher, GM.,Valtschanoff, JG.,Ma, YH.,...&Mei, L.(2003).Ligand-dependent recruitment of the ErbB4 signaling complex into neuronal lipid rafts.JOURNAL OF NEUROSCIENCE,23(8),3164-3175. |
| MLA | Ma, L,et al."Ligand-dependent recruitment of the ErbB4 signaling complex into neuronal lipid rafts".JOURNAL OF NEUROSCIENCE 23.8(2003):3164-3175. |
入库方式： OAI收割
来源：上海神经科学研究所
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