Na+ channel inactivation: a comparative study between pancreatic islet beta-cells and adrenal chromaffin cells in rat
文献类型：期刊论文
| 作者 | Lou, XL ; Yu, X ; Chen, XK ; Duan, KL ; He, LM ; Qu, AL ; Xu, T ; Zhou, Z |
| 刊名 | JOURNAL OF PHYSIOLOGY-LONDON
 |
| 出版日期 | 2003 |
| 卷号 | 548期号:1页码:191-202 |
| 关键词 | B-CELLS INSULIN-SECRETION ACTION-POTENTIALS PATCH-CLAMP QUANTAL SECRETION POTASSIUM CHANNEL IONIC CURRENTS CA2+ CURRENT CALCIUM SODIUM |
| ISSN号 | 0022-3751 |
| 通讯作者 | Zhou, Z (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China, |
| 英文摘要 | A comparative study was carried out on the inactivation of Na+ channels in two types of endocrine cells in rats, beta-cells and adrenal chromaffin cells (ACCs), using patch-clamp techniques. The beta-cells were very sensitive to hyperpolarization; the Na+ currents increased ninefold when the holding potential was shifted from -70 mV to -120 mV. ACCs were not sensitive to hyperpolarization. The half-inactivation voltages were -90 mV (rat beta-cells) and -62 mV (ACCs). The time constant for recovery from inactivation at -70 mV was 10.5 times slower in beta-cells (60 ms) than in ACCs (5.7 ms). The rate of Na+-channel inactivation at physiological resting potential was more than three times slower in beta-cells than in ACCs. Na+ influx through Na+ channels had no effect on the secretory machinery in rat beta-cells. However, these 'silent Na+ channels' could contribute to the generation of action potentials in some conditions, such as when the cell is hyperpolarized. It is concluded that the fractional availability of Na+ channels in beta-cells at a holding potential of -70 mV is about 15% of that in ACCs. This value in rat beta-cells is larger than that observed in mouse (0%), but is smaller than those observed in human or dog (90%). |
| 学科主题 | Neurosciences & Neurology ; Physiology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2024]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Lou, XL,Yu, X,Chen, XK,et al. Na+ channel inactivation: a comparative study between pancreatic islet beta-cells and adrenal chromaffin cells in rat[J]. JOURNAL OF PHYSIOLOGY-LONDON,2003,548(1):191-202. |
| APA | Lou, XL.,Yu, X.,Chen, XK.,Duan, KL.,He, LM.,...&Zhou, Z.(2003).Na+ channel inactivation: a comparative study between pancreatic islet beta-cells and adrenal chromaffin cells in rat.JOURNAL OF PHYSIOLOGY-LONDON,548(1),191-202. |
| MLA | Lou, XL,et al."Na+ channel inactivation: a comparative study between pancreatic islet beta-cells and adrenal chromaffin cells in rat".JOURNAL OF PHYSIOLOGY-LONDON 548.1(2003):191-202. |
入库方式： OAI收割
来源：上海神经科学研究所
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