Rapid inhibitory effects of corticosterone on calcium influx in rat dorsal root ganglion neurons
文献类型：期刊论文
| 作者 | He, LM ; Zhang, CG ; Zhou, Z ; Xu, T |
| 刊名 | NEUROSCIENCE
 |
| 出版日期 | 2003 |
| 卷号 | 116期号:2页码:325-333 |
| 关键词 | corticosterone dorsal root ganglion calcium channel protein kinase C PROTEIN-KINASE-C N-TYPE CHANNEL BLOCKERS CA2+ CHANNEL PC12 CELLS P-TYPE GLUCOCORTICOIDS FORMALIN RELEASE DEXAMETHASONE |
| ISSN号 | 0306-4522 |
| 通讯作者 | Xu, T (reprint author), Huazhong Univ Sci & Technol, Inst Biophys & Biochem, Wuhan 430074, Peoples R China, |
| 英文摘要 | Corticosterone may nongenomically affect cell functions in addition to its well-characterized effects on gene expression. The purpose of this study is to examine if corticosterone has a rapid nongenomic effect on excitability of dorsal root ganglion neurons by using patch-clamp and single-cell Ca2+ microfluometry techniques. The results show that corticosterone has a dose-dependent rapid inhibitory effect on the voltage-dependent calcium currents in dorsal root ganglion neurons. Moreover, corticosterone inhibits [Ca2+](i) elevation induced by 50 mM high K+ within just 3 s. The inhibitory effects of corticosterone on the voltage-dependent calcium current and high K+-induced calcium influx diminish after adding protein kinase C inhibitor or pretreatment with pertussis toxin for 24 h. Our results demonstrate an nongenomic effect of corticosterone on the excitability of dorsal root ganglion neurons and the effect is mediated through a putative pertussis toxin-sensitive G-protein-coupled receptor and activation of protein kinase C. (C) 2003 IBRO. Published by Elsevier Science Ltd. All rights reserved. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2035]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | He, LM,Zhang, CG,Zhou, Z,et al. Rapid inhibitory effects of corticosterone on calcium influx in rat dorsal root ganglion neurons[J]. NEUROSCIENCE,2003,116(2):325-333. |
| APA | He, LM,Zhang, CG,Zhou, Z,&Xu, T.(2003).Rapid inhibitory effects of corticosterone on calcium influx in rat dorsal root ganglion neurons.NEUROSCIENCE,116(2),325-333. |
| MLA | He, LM,et al."Rapid inhibitory effects of corticosterone on calcium influx in rat dorsal root ganglion neurons".NEUROSCIENCE 116.2(2003):325-333. |
入库方式： OAI收割
来源：上海神经科学研究所
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