Regulation of AChR clustering by dishevelled interacting with MuSK and PAK1
文献类型：期刊论文
| 作者 | Luo, ZG ; Wang, Q ; Zhou, JZ ; Wang, JB ; Luo, ZJ ; Liu, MY ; He, X ; Wynshaw-Boris, A ; Xiong, WC ; Lu, B ; Mei, L |
| 刊名 | NEURON
 |
| 出版日期 | 2002 |
| 卷号 | 35期号:3页码:489-505 |
| 关键词 | RECEPTOR TYROSINE KINASE NICOTINIC ACETYLCHOLINE-RECEPTOR NEUROMUSCULAR SYNAPSE FORMATION POLARITY GENE POSTSYNAPTIC APPARATUS JUXTAMEMBRANE REGION SIGNALING PATHWAYS SKELETAL-MUSCLE CELL POLARITY CRD DOMAIN |
| ISSN号 | 0896-6273 |
| 通讯作者 | Mei, L (reprint author), Univ Alabama, Civitan Int Res Ctr, Dept Neurobiol, 1530 3rd Ave S, Birmingham, AL 35294 USA, |
| 英文摘要 | An important aspect of synapse development is the clustering of neurotransmitter receptors in the postsynaptic membrane. Although MuSK is required for acetylcholine receptor (AChR) clustering at the neuromuscular junction (NMJ), the underlying molecular mechanisms remain unclear. We report here that in muscle cells, MuSK interacts with Dishevelled (Dvl), a signaling molecule important for planar cell polarity. Disruption of the MuSK-Dvl interaction inhibits Agrin- and neuron-induced AChR clustering. Expression of dominant-negative Dvl1 in postsynaptic muscle cells reduces the amplitude of spontaneous synaptic currents at the NMJ. Moreover, Dvl1 interacts with downstream kinase PAK1. Agrin activates PAK, and this activation requires Dvl. Inhibition of PAK1 activity attenuates AChR clustering. These results demonstrate important roles of DO and PAK in Agrin/MuSK-induced AChR clustering and reveal a novel function of Dvl in synapse development. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2046]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Luo, ZG,Wang, Q,Zhou, JZ,et al. Regulation of AChR clustering by dishevelled interacting with MuSK and PAK1[J]. NEURON,2002,35(3):489-505. |
| APA | Luo, ZG.,Wang, Q.,Zhou, JZ.,Wang, JB.,Luo, ZJ.,...&Mei, L.(2002).Regulation of AChR clustering by dishevelled interacting with MuSK and PAK1.NEURON,35(3),489-505. |
| MLA | Luo, ZG,et al."Regulation of AChR clustering by dishevelled interacting with MuSK and PAK1".NEURON 35.3(2002):489-505. |
入库方式： OAI收割
来源：上海神经科学研究所
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