中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
GDNF acutely modulates excitability and A-type K+ channels in midbrain dopaminergic neurons

文献类型:期刊论文

作者Yang, F ; Feng, LY ; Zheng, F ; Johnson, SW ; Du, J ; Shen, LY ; Wu, CP ; Lu, B
刊名NATURE NEUROSCIENCE
出版日期2001
卷号4期号:11页码:1071-1078
关键词VENTRAL MESENCEPHALIC NEURONS MICE LACKING GDNF NEUROTROPHIC FACTOR NERVOUS-SYSTEM ELECTROPHYSIOLOGICAL PROPERTIES SYNAPTIC TRANSMISSION TYROSINE KINASE CATION CURRENT IN-VIVO RECEPTOR
ISSN号1097-6256
通讯作者Lu, B (reprint author), NICHHD, Unit Synapse Dev & Plast, LCSN, NIH, Bethesda, MD 20892 USA,
英文摘要Glial cell line-derived neurotrophic factor (GDNF) prevents lesion-induced death of midbrain dopaminergic neurons, but its function in normal brain remains uncertain. Here we show that GDNF acutely and reversibly potentiated the excitability of cultured midbrain neurons by inhibiting transient A-type K+ channels. The effects of GDNF were limited to large, tyrosine hydroxylase (TH)positive dopaminergic neurons, and were mediated by mitogen associated protein (MAP) kinase. Application of GDNF also elicited a MAP kinase-dependent enhancement of the excitability in dopaminergic neurons in midbrain slice. These results demonstrate an acute regulation of GDNF on ion channels and its underlying signaling mechanism, and reveal an unexpected role of GDNF in normal midbrain dopaminergic neurons.
学科主题Neurosciences & Neurology
收录类别SCI
语种英语
公开日期2012-07-23
源URL[http://ir.sibs.ac.cn/handle/331001/2069]  
专题上海神经科学研究所_神经所(总)
推荐引用方式
GB/T 7714
Yang, F,Feng, LY,Zheng, F,et al. GDNF acutely modulates excitability and A-type K+ channels in midbrain dopaminergic neurons[J]. NATURE NEUROSCIENCE,2001,4(11):1071-1078.
APA Yang, F.,Feng, LY.,Zheng, F.,Johnson, SW.,Du, J.,...&Lu, B.(2001).GDNF acutely modulates excitability and A-type K+ channels in midbrain dopaminergic neurons.NATURE NEUROSCIENCE,4(11),1071-1078.
MLA Yang, F,et al."GDNF acutely modulates excitability and A-type K+ channels in midbrain dopaminergic neurons".NATURE NEUROSCIENCE 4.11(2001):1071-1078.

入库方式: OAI收割

来源:上海神经科学研究所

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