The expression of calcitonin gene-related peptide in dorsal horn neurons of the mouse lumbar spinal cord
文献类型：期刊论文
| 作者 | Tie-Jun, SS ; Xu, Z ; Hokfelt, T |
| 刊名 | NEUROREPORT
 |
| 出版日期 | 2001 |
| 卷号 | 12期号:4页码:739-743 |
| 关键词 | dorsal root ganglia neuropeptide pain primary afferents sensory processing SENSORY NEURONS SUBSTANCE-P RAT NEUROPEPTIDES IMMUNOREACTIVITY GALANIN REFLEX TISSUE |
| ISSN号 | 0959-4965 |
| 通讯作者 | Hokfelt, T (reprint author), Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden, |
| 英文摘要 | Using immunohistochemistry and in situ hybridization the expression of calcitonin gene-related peptide (CGRP) was studied in the mouse spinal cord under normal conditions and after unilateral rhizotomy and after local colchicine treatment. Under normal conditions a dense plexus of CGRP-immunoreactive (IR) fibres was observed in the superfical layers of dorsal horns with lower numbers of fibers in deeper laminae. Seven days after unilateral rhizotomy, there was a marked reduction of CGRP-IR fibres in the ipsilateral superfical layers and distinctly CGRP-IR neurons could be detected in the ipsilateral lamina III. CGRP mRNA-positive neurons were observed in lamina III in both the ipsilateral and contralateral dorsal horn. Colchicine treatment did not markedly increase the number of CGRP-IR neurons. The results suggest that CGRP is synthesized in local dorsal horn neurons of the mouse, and these neurons presumably participate in sensory processing. NeuroReport 12:739-743 (C) 2001 Lippincott Williams & Wilkins. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2077]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Tie-Jun, SS,Xu, Z,Hokfelt, T. The expression of calcitonin gene-related peptide in dorsal horn neurons of the mouse lumbar spinal cord[J]. NEUROREPORT,2001,12(4):739-743. |
| APA | Tie-Jun, SS,Xu, Z,&Hokfelt, T.(2001).The expression of calcitonin gene-related peptide in dorsal horn neurons of the mouse lumbar spinal cord.NEUROREPORT,12(4),739-743. |
| MLA | Tie-Jun, SS,et al."The expression of calcitonin gene-related peptide in dorsal horn neurons of the mouse lumbar spinal cord".NEUROREPORT 12.4(2001):739-743. |
入库方式： OAI收割
来源：上海神经科学研究所
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