Identification and characterization of differentially expressed genes in denervated muscle
文献类型：期刊论文
| 作者 | Tang, H ; Cheung, WMW ; Ip, FCF ; Ip, NV |
| 刊名 | MOLECULAR AND CELLULAR NEUROSCIENCE
 |
| 出版日期 | 2000 |
| 卷号 | 16期号:2页码:127-140 |
| 关键词 | NEUROTROPHIC FACTOR-RECEPTOR ARBITRARILY PRIMED PCR TUMOR-NECROSIS-FACTOR RAT FACIAL MUSCLE SKELETAL-MUSCLE MESSENGER-RNA PLASMINOGEN-ACTIVATOR TRANSGENIC MICE MOTOR NEURONS DISPLAY |
| ISSN号 | 1044-7431 |
| 通讯作者 | Tang, H (reprint author), Chinese Acad Sci, Shanghai Res Ctr Life Sci, Shanghai, Peoples R China, |
| 英文摘要 | Denervation results in a series of changes in skeletal muscle. To elucidate the molecular basis underlying these changes, it is important to identify the profile of altered gene expression in skeletal muscle following nerve injury. In the present study, we have examined the differentially expressed genes in denervated gastrocnemius muscle using RNA fingerprinting by arbitrarily primed PCR. Eight differentially expressed mRNA transcripts have been identified. A bilateral regulatory profile can be observed for the up-regulated genes in both denervated and contralateral control muscle following unilateral sciatic nerve injury. The temporal expression profiles of the denervation-regulated genes in muscle during development, together with their dependency on nerve activity, suggest potential functional roles following nerve injury in vivo. In particular, the identification of two apoptosis-related genes in denervated muscle provides molecular evidence that the apoptotic process is likely to be involved in the intricate changes that lead to muscle atrophy. Our findings not only allow the identification of novel genes, but also suggest possible functions for some known genes in muscle following nerve injury. Taken together, these findings provide important insights into our understanding of the molecular events in denervated muscle and suggest that the differentially expressed genes may play potential roles during muscle denervation and regeneration. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2086]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Tang, H,Cheung, WMW,Ip, FCF,et al. Identification and characterization of differentially expressed genes in denervated muscle[J]. MOLECULAR AND CELLULAR NEUROSCIENCE,2000,16(2):127-140. |
| APA | Tang, H,Cheung, WMW,Ip, FCF,&Ip, NV.(2000).Identification and characterization of differentially expressed genes in denervated muscle.MOLECULAR AND CELLULAR NEUROSCIENCE,16(2),127-140. |
| MLA | Tang, H,et al."Identification and characterization of differentially expressed genes in denervated muscle".MOLECULAR AND CELLULAR NEUROSCIENCE 16.2(2000):127-140. |
入库方式： OAI收割
来源：上海神经科学研究所
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