Embryonic expression and extracellular secretion of Xenopus slit
文献类型：期刊论文
| 作者 | Chen, JH ; Wu, W ; Li, HS ; Fagaly, T ; Zhou, L ; Wu, JY ; Rao, Y |
| 刊名 | NEUROSCIENCE
 |
| 出版日期 | 2000 |
| 卷号 | 96期号:1页码:231-236 |
| 关键词 | slit roundabout olfactory bulb axon guidance chemorepulsion GROWTH CONE GUIDANCE CHICK NERVOUS-SYSTEM AXON GUIDANCE C-ELEGANS SPINAL-CORD SEMAPHORIN-III CNS MIDLINE DROSOPHILA-MELANOGASTER COLORECTAL-CANCER MOLECULAR-BIOLOGY |
| ISSN号 | 0306-4522 |
| 通讯作者 | Rao, Y (reprint author), Washington Univ, Sch Med, Dept Anat & Neurobiol, Box 8108,660 S Euclid Ave, St Louis, MO 63110 USA, |
| 英文摘要 | The slit genes have recently been found to encode proteins with a conserved chemorepulsive activity for axons in invertebrates and vertebrates. We have determined the expression pattern of a slit gene in Xenopus embryos. In the neural tube, slit is expressed at the ventral and dorsal midlines, and the motor neurons. slit is also expressed in a changing pattern in the retina. The full-length Xenopus Slit protein is secreted extracellularly, whereas its receptor Roundabout can not be secreted. Using a myc-tagged secreted Slit protein, we confirmed the binding of Slit to Roundabout expressed on the cell surface. These results confirm Slit-Roundabout interactions and the biochemical properties of Slit and Roundabout proteins, and further support the idea that Slit may guide axon projections in multiple regions of the embryo. (C) 2000 IBRO. Published by Elsevier Science Ltd. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2097]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Chen, JH,Wu, W,Li, HS,et al. Embryonic expression and extracellular secretion of Xenopus slit[J]. NEUROSCIENCE,2000,96(1):231-236. |
| APA | Chen, JH.,Wu, W.,Li, HS.,Fagaly, T.,Zhou, L.,...&Rao, Y.(2000).Embryonic expression and extracellular secretion of Xenopus slit.NEUROSCIENCE,96(1),231-236. |
| MLA | Chen, JH,et al."Embryonic expression and extracellular secretion of Xenopus slit".NEUROSCIENCE 96.1(2000):231-236. |
入库方式： OAI收割
来源：上海神经科学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。