中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
The mouse SLIT family: Secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance

文献类型:期刊论文

作者Yuan, WL ; Zhou, LJ ; Chen, TH ; Wu, JY ; Rao, Y ; Ornitz, DM
刊名DEVELOPMENTAL BIOLOGY
出版日期1999
卷号212期号:2页码:290-306
关键词NEURAL CREST MIGRATION NERVOUS-SYSTEM CNS MIDLINE MOLECULAR-CLONING LIMB DEVELOPMENT SPINAL-CORD MOTOR AXONS CHICK DROSOPHILA PROTEINS
ISSN号0012-1606
通讯作者Ornitz, DM (reprint author), Washington Univ, Sch Med, Dept Mol Biol & Pharmacol, 660 S Euclid Ave, St Louis, MO 63110 USA,
英文摘要The Slit gene encodes a secreted molecule essential for neural development in Drosophila embryos. Here we report the identification of three Slit homologues in the mouse. We demonstrate that the mouse SLIT1 protein can bind ROBO1, a transmembrane receptor implicated in axon guidance. Both whole-mount and section in situ hybridization studies reveal unique and complementary patterns of expression of the three mouse Slit genes and of Robo1, both within the central nervous system and in other developing tissues. The complementary expression patterns of Slit and Robo1 and their in vitro interaction suggest a ligand-receptor relationship. The expression of all three Slit genes in the floor plate suggests that they are likely to share the same functional properties with their Drosophila homologue in midline neural development and axon guidance. The complementary expression of Slit and Robo1 in different subdivisions of the somites suggests their possible function in axon pathfinding and neural crest cell migration. The unique expression pattern in Limb and other organs indicates additional potential functions of the Slit gene family. (C) 1999 Academic Press.
学科主题Developmental Biology
收录类别SCI
语种英语
公开日期2012-07-23
源URL[http://ir.sibs.ac.cn/handle/331001/2099]  
专题上海神经科学研究所_神经所(总)
推荐引用方式
GB/T 7714
Yuan, WL,Zhou, LJ,Chen, TH,et al. The mouse SLIT family: Secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance[J]. DEVELOPMENTAL BIOLOGY,1999,212(2):290-306.
APA Yuan, WL,Zhou, LJ,Chen, TH,Wu, JY,Rao, Y,&Ornitz, DM.(1999).The mouse SLIT family: Secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance.DEVELOPMENTAL BIOLOGY,212(2),290-306.
MLA Yuan, WL,et al."The mouse SLIT family: Secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance".DEVELOPMENTAL BIOLOGY 212.2(1999):290-306.

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来源:上海神经科学研究所

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