Directional guidance of neuronal migration in the olfactory system by the protein Slit
文献类型：期刊论文
| 作者 | Wu, W ; Wong, K ; Chen, JH ; Jiang, ZH ; Dupuls, S ; Wu, JY ; Rao, Y |
| 刊名 | NATURE
 |
| 出版日期 | 1999 |
| 卷号 | 400期号:6742页码:331-336 |
| 关键词 | SUBVENTRICULAR ZONE CELLS NEURAL CREST MIGRATION FETAL MONKEY NEOCORTEX POLYSIALIC ACID NERVOUS-SYSTEM AXON GUIDANCE GENE ENCODES C-ELEGANS GLIA PRECURSORS |
| ISSN号 | 0028-0836 |
| 通讯作者 | Wu, JY (reprint author), Washington Univ, Sch Med, Dept Anat & Neurobiol, Box 8108,660 S Euclid Ave, St Louis, MO 63110 USA, |
| 英文摘要 | Although cell migration is crucial for neural development, molecular mechanisms guiding neuronal migration have remained unclear. Here we report that the secreted protein Slit repels neuronal precursors migrating from the anterior subventricular zone in the telencephalon to the olfactory bulb. Our results provide a direct demonstration of a molecular cue whose concentration gradient guides the direction of migrating neurons. They also support a common guidance mechanism for axon projection and neuronal migration and suggest that Slit may provide a molecular tool with potential therapeutic applications in controlling and directing cell migration. |
| 学科主题 | Science & Technology - Other Topics |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2100]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Wu, W,Wong, K,Chen, JH,et al. Directional guidance of neuronal migration in the olfactory system by the protein Slit[J]. NATURE,1999,400(6742):331-336. |
| APA | Wu, W.,Wong, K.,Chen, JH.,Jiang, ZH.,Dupuls, S.,...&Rao, Y.(1999).Directional guidance of neuronal migration in the olfactory system by the protein Slit.NATURE,400(6742),331-336. |
| MLA | Wu, W,et al."Directional guidance of neuronal migration in the olfactory system by the protein Slit".NATURE 400.6742(1999):331-336. |
入库方式： OAI收割
来源：上海神经科学研究所
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