Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons
文献类型：期刊论文
| 作者 | Li, HS ; Chen, JH ; Wu, W ; Fagaly, T ; Zhou, LJ ; Yuan, WL ; Dupuis, S ; Jiang, ZH ; Nash, W ; Gick, C ; Ornitz, DM ; Wu, JY ; Rao, Y |
| 刊名 | CELL
 |
| 出版日期 | 1999 |
| 卷号 | 96期号:6页码:807-818 |
| 关键词 | GROWTH CONE GUIDANCE ODORANT RECEPTOR EXPRESSION CENTRAL-NERVOUS-SYSTEM DORSAL-ROOT GANGLIA MITRAL TUFTED CELLS EMBRYO SPINAL-CORD C-ELEGANS COMMISSURAL AXONS MOTOR AXONS FLOOR-PLATE |
| ISSN号 | 0092-8674 |
| 通讯作者 | Wu, JY (reprint author), Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA,jwu@pharmdec.wustl.edu ; raoyi@thalamus.wustl.edu |
| 英文摘要 | The olfactory bulb plays a central role in olfactory information processing through its connections with both peripheral and cortical structures. Axons projecting from the olfactory bulb to the telencephalon are guided by a repulsive activity in the septum. The molecular nature of the repellent is not known. We report here the isolation of vertebrate homologs of the Drosophila slit gene and show that Slit protein binds to the transmembrane protein Roundabout (Robo). Slit is expressed in the septum whereas Robe is expressed in the olfactory bulb. Functionally, Slit acts as a chemorepellent for olfactory bulb axons. These results establish a ligand-receptor relationship between two molecules important for neural development, suggest a role for Slit in olfactory bulb axon guidance, and reveal the existence of a new family of axon guidance molecules. |
| 学科主题 | Biochemistry & Molecular Biology ; Cell Biology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2104]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Li, HS,Chen, JH,Wu, W,et al. Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons[J]. CELL,1999,96(6):807-818. |
| APA | Li, HS.,Chen, JH.,Wu, W.,Fagaly, T.,Zhou, LJ.,...&Rao, Y.(1999).Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons.CELL,96(6),807-818. |
| MLA | Li, HS,et al."Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons".CELL 96.6(1999):807-818. |
入库方式： OAI收割
来源：上海神经科学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。