Determination of a novel diarylheptanoid (Juglanin B) from green walnut husks (Juglans regia L.) in rat plasma by high-performance liquid Chromatography
文献类型：期刊论文
| 作者 | Liu JX(柳军玺) ; Di DL(邸多隆); Huang XY(黄新异)
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| 刊名 | Biomedical Chromatography
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| 出版日期 | 2010 |
| 卷号 | 24期号:3页码:307-311 |
| 关键词 | Juglans regia L. diarylheptanoid Juglanin B pharmacokinetics |
| ISSN号 | 1099-0801 |
| 通讯作者 | 邸多隆 |
| 中文摘要 | A simple and reliable analytical method based on high-performance liquid chromatography (HPLC) coupled with a diode array detector (DAD) was developed for the determination of a novel diarylheptanoid (Juglanin B) from green walnut husks (Juglans regia L.) in rat plasma using rhoiptelol as an internal standard. Chromatographic separation was carried out on a Sinochrom ODS-AP C18 column (250 ￥ 4.6 mm i.d., 5 mm) with acetonitrile–10 mM postassium dihydrogen phosphate (pH = 3; 55:45, v/v) as mobile phase, and the detection wavelength was set at 214 nm. The plasma samples were prepared using methanol as protein precipitator. The extraction recovery of Juglanin B ranged from 70.26 to 78.59%, and the calibration curve had a good linearity in the range 0.08–50 mg/mL (r2 = 0.9932). The RSDs of intra- and inter-day precision ranged from 1.19 to 4.92% and 4.35 to 4.54%, respectively. The HPLC-DAD method described is a simple, rapid and reliable method for the determination of Juglanin B level and for use in studies involving pharmacokinetics. |
| 学科主题 | 分析化学与药物化学 |
| 收录类别 | SCI |
| 资助信息 | the “Hundred Talents Program”of the Chinese Academy of Sciences (CAS);the National Natural Sciences Foundation of China (NSFC no.20775083) |
| 语种 | 英语 |
| WOS记录号 | WOS:000274938500012 |
| 公开日期 | 2012-10-08 |
| 源URL | [http://210.77.64.217/handle/362003/1262]  |
| 专题 | 兰州化学物理研究所_中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| 通讯作者 | Di DL(邸多隆) |
| 推荐引用方式 GB/T 7714 | Liu JX,Di DL,Huang XY. Determination of a novel diarylheptanoid (Juglanin B) from green walnut husks (Juglans regia L.) in rat plasma by high-performance liquid Chromatography[J]. Biomedical Chromatography,2010,24(3):307-311. |
| APA | 柳军玺,邸多隆,&黄新异.(2010).Determination of a novel diarylheptanoid (Juglanin B) from green walnut husks (Juglans regia L.) in rat plasma by high-performance liquid Chromatography.Biomedical Chromatography,24(3),307-311. |
| MLA | 柳军玺,et al."Determination of a novel diarylheptanoid (Juglanin B) from green walnut husks (Juglans regia L.) in rat plasma by high-performance liquid Chromatography".Biomedical Chromatography 24.3(2010):307-311. |
入库方式： OAI收割
来源：兰州化学物理研究所
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