Discovery and Identification of 2-Phenylethyl 2,6-Dihydroxybenzoate as a Natural Lipid-Lowering Lead
文献类型：期刊论文
| 作者 | Luo, Yinggang ; Li, Guangzhou ; Li, Guoyou ; Yan, Jufang ; Yi, Jinhai ; Zhang, Guolin |
| 刊名 | PLANTA MEDICA
 |
| 出版日期 | 2011 |
| 卷号 | 77期号:18页码:2047-2049 |
| 关键词 | Lipid-lowering benzoate Geophila herbacea Rubiaceae LDLR-Luc reporter gene system |
| ISSN号 | 0032-0943 |
| 产权排序 | 1 |
| 通讯作者 | Luo, YG (reprint author), Chinese Acad Sci, Ctr Nat Prod Res, Chengdu Inst Biol, 9 Sect,4 Renmin Rd S, Chengdu 610041, Peoples R China. |
| 英文摘要 | Guided by lipid-lowering assays, a new compound (1, 2-phenylethyl 2,6-dihydroxybenzoate) was isolated from the ethanolic extract of Geophila herbacea. The structure of 1 was determined unambiguously by spectral data interpretation and confirmed by X-ray crystallographic analysis. Preliminary dose-dependency of 1 verified its lipid-lowering bioactivity in vitro. A facile chemical synthesis for 1 was performed to provide a practical approach for further studies on structure-activity relationship. |
| 学科主题 | Plant Sciences; Pharmacology & Pharmacy |
| 收录类别 | SCI |
| 资助信息 | Chinese Academy of Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000298852000014 |
| 公开日期 | 2012-11-09 |
| 源URL | [http://210.75.237.14/handle/351003/23519]  |
| 专题 | 成都生物研究所_天然产物研究 |
| 推荐引用方式 GB/T 7714 | Luo, Yinggang,Li, Guangzhou,Li, Guoyou,et al. Discovery and Identification of 2-Phenylethyl 2,6-Dihydroxybenzoate as a Natural Lipid-Lowering Lead[J]. PLANTA MEDICA,2011,77(18):2047-2049. |
| APA | Luo, Yinggang,Li, Guangzhou,Li, Guoyou,Yan, Jufang,Yi, Jinhai,&Zhang, Guolin.(2011).Discovery and Identification of 2-Phenylethyl 2,6-Dihydroxybenzoate as a Natural Lipid-Lowering Lead.PLANTA MEDICA,77(18),2047-2049. |
| MLA | Luo, Yinggang,et al."Discovery and Identification of 2-Phenylethyl 2,6-Dihydroxybenzoate as a Natural Lipid-Lowering Lead".PLANTA MEDICA 77.18(2011):2047-2049. |
入库方式： OAI收割
来源：成都生物研究所
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