Self-aggregates of cholesterol-modified carboxymethyl konjac glucomannan conjugate: Preparation, characterization, and preliminary assessment as a carrier of etoposide
文献类型：期刊论文
| 作者 | Ha, Wei ; Wu, Hao ; Wang, Xiao-Ling ; Peng, Shu-Lin ; Ding, Li-Sheng ; Zhang, Sheng ; Li, Bang-Jing |
| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2011 |
| 卷号 | 86期号:2页码:513-519 |
| 关键词 | Carboxymethyl konjac glucomannan Cholesterol Nanoparticles Drug carrier Etoposide In vitro release |
| ISSN号 | 0144-8617 |
| 产权排序 | 1 |
| 通讯作者 | Zhang, Sheng ; Li, Bang-Jing |
| 英文摘要 | Various cholesterol (CH) bearing carboxymethyl konjac glucomannan (CKGM) amphiphilic conjugates (denoted CHCKGM) were synthesized using CKGM as hydrophilic segments and CH as hydrophobic parts. Structural characteristics of these CHCKGM conjugates were investigated using FTIR, (1)H NMR and thermogravimetric analysis (TGA). The properties of these self-aggregates were analysed by dynamic laser light-scattering (DLS), zeta potential, transmission electron microscopy (TEM) and the fluorescence probe technologies. The critical aggregation concentration (cac) of CHCKGM conjugates (2.59 x 10(-3) to 5.89 x 10(-3) mg/mL) was comparatively low, suggesting that the cholesterol fragment was very effective for forming aggregates. Etoposide was physically entrapped into the CHCKGM nanoparticles by sonication method. The in vitro release behavior of etoposide from CHCKGM nanoparticles revealed a sustained release property. Furthermore, these self-aggregated nanoparticles showed pH- and ionic strength-dependent properties which caused a considerable change in their radius. (C) 2011 Elsevier Ltd. All rights reserved. |
| 学科主题 | Chemistry; Polymer Science |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China (NSFC)[21074138, 51073107, 50703025]; CAS[KSCX2-EW-J-22]; State Key Laboratory of Polymer Materials Engineering (Sichuan University)[KF201003] |
| 语种 | 英语 |
| WOS记录号 | WOS:000294187400016 |
| 公开日期 | 2012-11-09 |
| 源URL | [http://210.75.237.14/handle/351003/23533]  |
| 专题 | 成都生物研究所_天然产物研究 |
| 推荐引用方式 GB/T 7714 | Ha, Wei,Wu, Hao,Wang, Xiao-Ling,et al. Self-aggregates of cholesterol-modified carboxymethyl konjac glucomannan conjugate: Preparation, characterization, and preliminary assessment as a carrier of etoposide[J]. CARBOHYDRATE POLYMERS,2011,86(2):513-519. |
| APA | Ha, Wei.,Wu, Hao.,Wang, Xiao-Ling.,Peng, Shu-Lin.,Ding, Li-Sheng.,...&Li, Bang-Jing.(2011).Self-aggregates of cholesterol-modified carboxymethyl konjac glucomannan conjugate: Preparation, characterization, and preliminary assessment as a carrier of etoposide.CARBOHYDRATE POLYMERS,86(2),513-519. |
| MLA | Ha, Wei,et al."Self-aggregates of cholesterol-modified carboxymethyl konjac glucomannan conjugate: Preparation, characterization, and preliminary assessment as a carrier of etoposide".CARBOHYDRATE POLYMERS 86.2(2011):513-519. |
入库方式： OAI收割
来源：成都生物研究所
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