Synthesis and Selective Estrogen Receptor Binding Affinity of 7-Hydroxylisoflavones
文献类型：期刊论文
| 作者 | Wang Xing ; Lu Guangying ; Yang Lijuan ; Wang Fei ; Wang Chun |
| 刊名 | CHINESE JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2011 |
| 卷号 | 31期号:8页码:1245-1251 |
| 关键词 | 7-hydroIsoflavone estrogen receptor binding affinity structure-activity relationship (SAR) |
| ISSN号 | 0253-2786 |
| 其他题名 | 7-羟基异黄酮及其衍生物的合成与选择性雌激素受体结合的构效关系研究 |
| 产权排序 | 1 |
| 通讯作者 | Wang Chun |
| 英文摘要 | Twenty six 7-hydroxylisoflavones, including four new compounds 3r, 3s, 3u and 3v, were successfully synthesized. Among which twenty four, 3a similar to 3x, were directly given by "One-Pot" strategy from polyphenolic compounds and substituted phenylacetic acids. 2'-Hydroxylisoflavones 4a and 4b were further developed from 2'-methoxylisoflvones 3d and 3g by demethylation. Nine out of twenty-six synthesized compounds exhibited higher selectivity for estrogen receptor ER beta than genistein; 7,8-dihydroxylisoflavones showed better binding affinities for ER P than 7-hydroxylisoflavones; 4'-substituents of isoflavones influenced relative binding affinities (RBA) of ER beta/ER alpha in the order: H>Cl>F>OH; 2', 3' and 5'-substituents reduced the binding affinity to both ER alpha and ER beta. |
| 学科主题 | Chemistry |
| 收录类别 | SCI |
| 语种 | 中文 |
| WOS记录号 | WOS:000294738900013 |
| 公开日期 | 2012-11-09 |
| 源URL | [http://210.75.237.14/handle/351003/23534]  |
| 专题 | 成都生物研究所_天然产物研究 |
| 推荐引用方式 GB/T 7714 | Wang Xing,Lu Guangying,Yang Lijuan,et al. Synthesis and Selective Estrogen Receptor Binding Affinity of 7-Hydroxylisoflavones[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2011,31(8):1245-1251. |
| APA | Wang Xing,Lu Guangying,Yang Lijuan,Wang Fei,&Wang Chun.(2011).Synthesis and Selective Estrogen Receptor Binding Affinity of 7-Hydroxylisoflavones.CHINESE JOURNAL OF ORGANIC CHEMISTRY,31(8),1245-1251. |
| MLA | Wang Xing,et al."Synthesis and Selective Estrogen Receptor Binding Affinity of 7-Hydroxylisoflavones".CHINESE JOURNAL OF ORGANIC CHEMISTRY 31.8(2011):1245-1251. |
入库方式： OAI收割
来源：成都生物研究所
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