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Organocatalytic Direct Asymmetric Aldol Reactions of 3-Isothiocyanato Oxindoles to Ketones: Stereocontrolled Synthesis of Spirooxindoles Bearing Highly Congested Contiguous Tetrasubstituted Stereocenters
文献类型：期刊论文
| 作者 | Chen, Wen-Bing ; Wu, Zhi-Jun ; Hu, Jing ; Cun, Lin-Feng ; Zhang, Xiao-Mei ; Yuan, Wei-Cheng |
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2011 |
| 卷号 | 13期号:9页码:2472-2475 |
| ISSN号 | 1523-7060 |
| 产权排序 | 2 |
| 通讯作者 | Yuan, WC (reprint author), Chinese Acad Sci, Chengdu Inst Organ Chem, Chengdu 610041, Peoples R China. |
| 英文摘要 | The first example of a direct catalytic asymmetric intermolecular aldol reaction of 3-isothiocyanato oxindoles to simple ketones with bifunctional thiourea-tertiary amine as catalyst is reported. This strategy provides a promising approach for the asymmetric synthesis of a range of enantioenriched spirocyclic oxindoles bearing two highly congested contiguous tetrasubstituted carbon stereocenters. Versatile transformations of the spirocyclic oxindole products into other structurally diverse spirocyclic oxindoles have also been demonstrated. |
| 学科主题 | Chemistry |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China[20802074]; National Basic Research Program of China (973 Program)[2010CB833300] |
| 语种 | 英语 |
| WOS记录号 | WOS:000289956700085 |
| 公开日期 | 2012-11-09 |
| 源URL | [http://210.75.237.14/handle/351003/23549]  |
| 专题 | 成都生物研究所_天然产物研究 |
| 推荐引用方式 GB/T 7714 | Chen, Wen-Bing,Wu, Zhi-Jun,Hu, Jing,et al. Organocatalytic Direct Asymmetric Aldol Reactions of 3-Isothiocyanato Oxindoles to Ketones: Stereocontrolled Synthesis of Spirooxindoles Bearing Highly Congested Contiguous Tetrasubstituted Stereocenters[J]. ORGANIC LETTERS,2011,13(9):2472-2475. |
| APA | Chen, Wen-Bing,Wu, Zhi-Jun,Hu, Jing,Cun, Lin-Feng,Zhang, Xiao-Mei,&Yuan, Wei-Cheng.(2011).Organocatalytic Direct Asymmetric Aldol Reactions of 3-Isothiocyanato Oxindoles to Ketones: Stereocontrolled Synthesis of Spirooxindoles Bearing Highly Congested Contiguous Tetrasubstituted Stereocenters.ORGANIC LETTERS,13(9),2472-2475. |
| MLA | Chen, Wen-Bing,et al."Organocatalytic Direct Asymmetric Aldol Reactions of 3-Isothiocyanato Oxindoles to Ketones: Stereocontrolled Synthesis of Spirooxindoles Bearing Highly Congested Contiguous Tetrasubstituted Stereocenters".ORGANIC LETTERS 13.9(2011):2472-2475. |
入库方式： OAI收割
来源：成都生物研究所
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