Preparation and antiherpetic activities of chemically modified polysaccharides from Polygonatum cyrtonema Hua
文献类型：期刊论文
| 作者 | Liu, Xiao-xiao ; Wan, Zhen-jiang ; Shi, Lin ; Lu, Xiao-xia |
| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2011 |
| 卷号 | 83期号:2页码:737-742 |
| 关键词 | Chemically modification Preparation Antiherpetic activity Polygonatum cyrtonema polysaccharide |
| ISSN号 | 0144-8617 |
| 产权排序 | 1 |
| 通讯作者 | Lu, XX (reprint author), Chinese Acad Sci, Nat Prod Res Ctr, Chengdu Inst Biol, Chengdu 610041, Peoples R China. |
| 英文摘要 | The chemically modified polysaccharides including sulfated phosphorylated carboxymethylated acetylated and sulfonylated derivatives were prepared from a neutral polysaccharide (PD) extracted from Polygonatum cyrtonema Hua These compounds were characterized by FT-IR H-1 NMR and C-13 NMR spectroscopy Antiherpetic activities of natural and modified P cyrtonema polysaccharide against herpes simplex virus (HSV) Induced by cyclophosphamide (CP) were then evaluated on vero cells using cytopathic effect (CPE) inhibition assay The phorphorylated derivative (P-PD) and sulfated derivative (S-PD) exhibited significant inhibitory activity against HSV in comparison with the native ones especially P-PD presented better antiviral potency In addition the sulfonylated derivative (Ts-PD) was found to be as effective as PD and the acetylated derivative (Ac-PD) to be slightly less antiviral effective whereas carboxymethylated derivative (C-PD) was shown to be almost inactive The results indicated that the types of function groups appeared to be very important for the antiherpetic activity of polysaccharides (C) 2010 Elsevier Ltd All rights reserved |
| 学科主题 | Chemistry; Polymer Science |
| 收录类别 | SCI |
| 资助信息 | National Science Foundation of China[20972153]; Chinese Academy of Sciences[CIB-2007-LYQY-06] |
| 语种 | 英语 |
| WOS记录号 | WOS:000285437000057 |
| 公开日期 | 2012-11-09 |
| 源URL | [http://210.75.237.14/handle/351003/23565]  |
| 专题 | 成都生物研究所_天然产物研究 |
| 推荐引用方式 GB/T 7714 | Liu, Xiao-xiao,Wan, Zhen-jiang,Shi, Lin,et al. Preparation and antiherpetic activities of chemically modified polysaccharides from Polygonatum cyrtonema Hua[J]. CARBOHYDRATE POLYMERS,2011,83(2):737-742. |
| APA | Liu, Xiao-xiao,Wan, Zhen-jiang,Shi, Lin,&Lu, Xiao-xia.(2011).Preparation and antiherpetic activities of chemically modified polysaccharides from Polygonatum cyrtonema Hua.CARBOHYDRATE POLYMERS,83(2),737-742. |
| MLA | Liu, Xiao-xiao,et al."Preparation and antiherpetic activities of chemically modified polysaccharides from Polygonatum cyrtonema Hua".CARBOHYDRATE POLYMERS 83.2(2011):737-742. |
入库方式： OAI收割
来源：成都生物研究所
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