中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Preparation and antiherpetic activities of chemically modified polysaccharides from Polygonatum cyrtonema Hua

文献类型:期刊论文

作者Liu, Xiao-xiao ; Wan, Zhen-jiang ; Shi, Lin ; Lu, Xiao-xia
刊名CARBOHYDRATE POLYMERS
出版日期2011
卷号83期号:2页码:737-742
关键词Chemically modification Preparation Antiherpetic activity Polygonatum cyrtonema polysaccharide
ISSN号0144-8617
产权排序1
通讯作者Lu, XX (reprint author), Chinese Acad Sci, Nat Prod Res Ctr, Chengdu Inst Biol, Chengdu 610041, Peoples R China.
英文摘要The chemically modified polysaccharides including sulfated phosphorylated carboxymethylated acetylated and sulfonylated derivatives were prepared from a neutral polysaccharide (PD) extracted from Polygonatum cyrtonema Hua These compounds were characterized by FT-IR H-1 NMR and C-13 NMR spectroscopy Antiherpetic activities of natural and modified P cyrtonema polysaccharide against herpes simplex virus (HSV) Induced by cyclophosphamide (CP) were then evaluated on vero cells using cytopathic effect (CPE) inhibition assay The phorphorylated derivative (P-PD) and sulfated derivative (S-PD) exhibited significant inhibitory activity against HSV in comparison with the native ones especially P-PD presented better antiviral potency In addition the sulfonylated derivative (Ts-PD) was found to be as effective as PD and the acetylated derivative (Ac-PD) to be slightly less antiviral effective whereas carboxymethylated derivative (C-PD) was shown to be almost inactive The results indicated that the types of function groups appeared to be very important for the antiherpetic activity of polysaccharides (C) 2010 Elsevier Ltd All rights reserved
学科主题Chemistry; Polymer Science
收录类别SCI
资助信息National Science Foundation of China[20972153]; Chinese Academy of Sciences[CIB-2007-LYQY-06]
语种英语
WOS记录号WOS:000285437000057
公开日期2012-11-09
源URL[http://210.75.237.14/handle/351003/23565]  
专题成都生物研究所_天然产物研究
推荐引用方式
GB/T 7714
Liu, Xiao-xiao,Wan, Zhen-jiang,Shi, Lin,et al. Preparation and antiherpetic activities of chemically modified polysaccharides from Polygonatum cyrtonema Hua[J]. CARBOHYDRATE POLYMERS,2011,83(2):737-742.
APA Liu, Xiao-xiao,Wan, Zhen-jiang,Shi, Lin,&Lu, Xiao-xia.(2011).Preparation and antiherpetic activities of chemically modified polysaccharides from Polygonatum cyrtonema Hua.CARBOHYDRATE POLYMERS,83(2),737-742.
MLA Liu, Xiao-xiao,et al."Preparation and antiherpetic activities of chemically modified polysaccharides from Polygonatum cyrtonema Hua".CARBOHYDRATE POLYMERS 83.2(2011):737-742.

入库方式: OAI收割

来源:成都生物研究所

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