Mechanisms of the interaction between Pr(DNR)(3) and herring-sperm DNA
文献类型：期刊论文
| 作者 | Liu, Xiaocai ; Wang, Xingming ; Ding, Lisheng |
| 刊名 | JOURNAL OF THE SERBIAN CHEMICAL SOCIETY
 |
| 出版日期 | 2011 |
| 卷号 | 76期号:10页码:1365-1378 |
| 关键词 | daunorubicin rare earth complexes herring-sperm DNA acridine orange interaction mechanism |
| ISSN号 | 0352-5139 |
| 产权排序 | 2 |
| 通讯作者 | Wang, XM (reprint author), SW Univ Sci & Technol, Sch Mat Sci & Engn, Mianyang 62101, Peoples R China. |
| 英文摘要 | Research on the interaction mechanism of drugs with DNA is essential to understand their pharmacokinetics. The interaction between rare earth complexes Pr(DNR)(3) and herring-sperm DNA was studied in Tris-HCl buffer solution (pH 7.4) by absorption and fluorescence spectroscopy and viscosity measurements. The results showed that the modes of interaction between Pr(DNR)(3) and herring-sperm DNA were electrostatic and intercalation. The binding ratio was n(Pr(DNA)3): n(DNA) = 5:1 and the binding constant was K-circle minus(292 K) = 4.34x10(3) L mol(-1). Furthermore, according to the double reciprocal method and the thermodynamic equation, the intercalative interaction was cooperatively driven by an enthalpy effect and an entropy effect. |
| 学科主题 | Chemistry |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China[30973634]; Postgraduate Innovation Foundation of Southwest University of Science and Technology. Mianyang, China |
| 语种 | 英语 |
| WOS记录号 | WOS:000296821000004 |
| 公开日期 | 2012-11-09 |
| 源URL | [http://210.75.237.14/handle/351003/23578]  |
| 专题 | 成都生物研究所_天然产物研究 |
| 推荐引用方式 GB/T 7714 | Liu, Xiaocai,Wang, Xingming,Ding, Lisheng. Mechanisms of the interaction between Pr(DNR)(3) and herring-sperm DNA[J]. JOURNAL OF THE SERBIAN CHEMICAL SOCIETY,2011,76(10):1365-1378. |
| APA | Liu, Xiaocai,Wang, Xingming,&Ding, Lisheng.(2011).Mechanisms of the interaction between Pr(DNR)(3) and herring-sperm DNA.JOURNAL OF THE SERBIAN CHEMICAL SOCIETY,76(10),1365-1378. |
| MLA | Liu, Xiaocai,et al."Mechanisms of the interaction between Pr(DNR)(3) and herring-sperm DNA".JOURNAL OF THE SERBIAN CHEMICAL SOCIETY 76.10(2011):1365-1378. |
入库方式： OAI收割
来源：成都生物研究所
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