Efficient ligand-free, palladium-catalyzed amidocarbonylation in ionic liquids: Facile synthesis of N-acyl-a-arylglycines
文献类型：期刊论文
| 作者 | Wang LL(王来来) ; Yang M(杨敏); Wang LL(王来来)
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| 刊名 | Synthetic Communications
 |
| 出版日期 | 2008 |
| 卷号 | 38页码:4460-4473 |
| 关键词 | Amidocarbonylation aromatic aldehyde ionic liquids N-acyl-a-arylglycine palladium |
| ISSN号 | 0039-7911 |
| 通讯作者 | 王来来 |
| 中文摘要 | A ligand-free, palladium-catalyzed amidocarbonylation reaction of aromatic aldehyde, acetamide, and CO in ionic liquids [C4mim]PF6, [C6mim]PF6, [C8mim]PF6, and [C6mim]BF4 as solvents is developed. The yields decreased in the order [C6mim]PF6>[C8mim]PF6>[C4mim]PF6>[C6mim]BF4, and substrate concentration affected the catalytic activity of amidocarbonylation. The excellent yield with up to 98% in amidocarbonylation of benzaldehyde was obtained using 15 mol% LiBr H2O and 6 mol% H2SO4 at 80 C. This reaction could proceed smoothly, resulting in several functionalized ortho-, meta-, and para-substituted N-acyl-a-phenylglycines in moderate to good yields, and o-tolualdehyde and mtolualdehyde as substrates were amidocarbonylated for the first time in [C6mim]PF6. A significant dependence of product yield on both substituent position and electronic effect of aromatic aldehyde was observed. The ligand-free synthetic method and convenient separation of the products highlighted the versatility of this newly developed methodology. |
| 学科主题 | 金属有机与超分子催化 |
| 收录类别 | SCI |
| 资助信息 | the National Natural Science Foundation of China (Nos. 20343005;20473107;20673130;20773147) |
| 语种 | 英语 |
| 公开日期 | 2012-11-09 |
| 源URL | [http://210.77.64.217/handle/362003/1928]  |
| 专题 | 兰州化学物理研究所_OSSO国家重点实验室 兰州化学物理研究所_ERC国家工程研究中心 |
| 通讯作者 | Wang LL(王来来); Wang LL(王来来) |
| 推荐引用方式 GB/T 7714 | Wang LL,Yang M,Wang LL. Efficient ligand-free, palladium-catalyzed amidocarbonylation in ionic liquids: Facile synthesis of N-acyl-a-arylglycines[J]. Synthetic Communications,2008,38:4460-4473. |
| APA | 王来来,杨敏,&王来来.(2008).Efficient ligand-free, palladium-catalyzed amidocarbonylation in ionic liquids: Facile synthesis of N-acyl-a-arylglycines.Synthetic Communications,38,4460-4473. |
| MLA | 王来来,et al."Efficient ligand-free, palladium-catalyzed amidocarbonylation in ionic liquids: Facile synthesis of N-acyl-a-arylglycines".Synthetic Communications 38(2008):4460-4473. |
入库方式： OAI收割
来源：兰州化学物理研究所
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