Investigation of Enantiomer Separation by LC with a New Bonded Cellulose 3,5-Dimethylphenylcarbamate Chiral Stationary Phase
文献类型：期刊论文
| 作者 | Zhao L(赵亮) ; Shi YP(师彦平)
|
| 刊名 | Chromatographia
 |
| 出版日期 | 2006 |
| 卷号 | 64期号:5/6页码:273-280 |
| 关键词 | Column liquid chromatograph Enantiomer separation Bonded cellulose 3 5-Dimethylphenylcarbamate |
| ISSN号 | 0009-5893 |
| 通讯作者 | 李永民 |
| 中文摘要 | A chiral stationary phase has been prepared from the 3,5-dimethylphenylcarbamate of cellulose chemically bonded to 3-aminopropylsilica gel at the 6-positions of the glucose units. The phase has been used to study direct liquid chromatographic enantioselective separation of five racemates. The effects on resolution of modifiers (alcohols, THF, and chloroform), flow rate, and temperature were investigated. It was found that the concentration and structure of the alcohol modifier can affect the separation; enantiomer separations were improved to different extents by addition of THF or chloroform to the mobile phase. Flow rate and temperature can also effect the resolution of racemates. In the range 10–40 C there was a linear relationship between ln k (or ln a) and 1/T (r > 0.98) for four of the compounds. These results indicate retention mechanism does not change as a function of temperature. |
| 学科主题 | 分析化学与药物化学 |
| 收录类别 | SCI |
| 资助信息 | the National Natural Science Foundation of China (No. 20375045);the Province Natural Science Foundation of Gansu (No. 3ZS041-A25-23);the Light in China’s Western Region (2003) |
| 语种 | 英语 |
| WOS记录号 | WOS:000241222200007 |
| 公开日期 | 2012-10-14 |
| 源URL | [http://210.77.64.217/handle/362003/1492]  |
| 专题 | 兰州化学物理研究所_中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| 推荐引用方式 GB/T 7714 | Zhao L,Shi YP. Investigation of Enantiomer Separation by LC with a New Bonded Cellulose 3,5-Dimethylphenylcarbamate Chiral Stationary Phase[J]. Chromatographia,2006,64(5/6):273-280. |
| APA | 赵亮,&师彦平.(2006).Investigation of Enantiomer Separation by LC with a New Bonded Cellulose 3,5-Dimethylphenylcarbamate Chiral Stationary Phase.Chromatographia,64(5/6),273-280. |
| MLA | 赵亮,et al."Investigation of Enantiomer Separation by LC with a New Bonded Cellulose 3,5-Dimethylphenylcarbamate Chiral Stationary Phase".Chromatographia 64.5/6(2006):273-280. |
入库方式： OAI收割
来源：兰州化学物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。