Anti-oxidative action of ent-kaurene diterpenoids
文献类型：期刊论文
| 作者 | Liu GA(刘国安) ; Ding L(丁兰) ; Yang Y(杨艳) ; Yang H(杨红) ; Yang QM(杨庆明) ; Wang HQ(汪汉卿) |
| 刊名 | Res. Chem. Intermed
 |
| 出版日期 | 2006 |
| 卷号 | 32期号:8页码:787-794 |
| 关键词 | DNA damage protection ent-kaurene diterpenoids inhibition lipid peroxidation comet assay |
| ISSN号 | 0922-6168 |
| 通讯作者 | 汪汉卿 |
| 中文摘要 | Nine ent-kaurene diterpenoids, leukamenin E, glaucocalyxin A, wangzaozi A, epinodisinol, epinodosin, rabdosin B, rabdosinate, lasiokaurin and oridonin, were separated from Isodon racemosa (Hemsl) Hara and Isodon japonica (Burm.f) Hara var. galaucocalyx (maxin). The protection against DNA damage induced by hydrogen peroxide in human peripheral blood mononuclear cells (PBMCs) and inhibition of lipid peroxidation in rat liver microsome were studied with comet assay and thiobarbituric acid reactive substances determination. All nine diterpenoids showed concentration-dependent protection in DNA damage in human PBMCs induced by 50 μMH2O2.The effects were similar and weaker than quercetin. The inhibitions of lipid peroxidation were obviously difference. Rabdosin B and oridonin were the strongest inhibitors, followed by lasiokaurin and wangzaozin A. Rabdosinate was the weakest and others were medium. The structure–activity relationship is discussed. |
| 学科主题 | 分析化学与药物化学 |
| 收录类别 | SCI |
| 资助信息 | NWNUKJCXGC-02;National Natural Science Foundation of China (No-20274034) |
| 语种 | 英语 |
| WOS记录号 | WOS:000242710400010 |
| 公开日期 | 2012-10-14 |
| 源URL | [http://210.77.64.217/handle/362003/1495]  |
| 专题 | 兰州化学物理研究所_中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| 推荐引用方式 GB/T 7714 | Liu GA,Ding L,Yang Y,et al. Anti-oxidative action of ent-kaurene diterpenoids[J]. Res. Chem. Intermed,2006,32(8):787-794. |
| APA | 刘国安,丁兰,杨艳,杨红,杨庆明,&汪汉卿.(2006).Anti-oxidative action of ent-kaurene diterpenoids.Res. Chem. Intermed,32(8),787-794. |
| MLA | 刘国安,et al."Anti-oxidative action of ent-kaurene diterpenoids".Res. Chem. Intermed 32.8(2006):787-794. |
入库方式： OAI收割
来源：兰州化学物理研究所
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