A pH sensitive nanocomposite microsphere based on chitosan and montmorillonite with in vitro reduction of the burst release effect
文献类型：期刊论文
| 作者 | Wang AQ(王爱勤)
|
| 刊名 | Drug Development and Industrial Pharmacy
 |
| 出版日期 | 2010 |
| 卷号 | 36期号:9页码:1106-1114 |
| 关键词 | Chitosan drug release montmorillonite nanocomposite ofloxacin |
| ISSN号 | 0363-9045 |
| 通讯作者 | 王爱勤 aqwang@licp.cas.cn |
| 中文摘要 | Objective: The aim of this study was to prepare pH-sensitive ofloxacin (OFL)/montmorillonite (MMT)/chitosan (CTS) nanocomposite microspheres that improve the burst release effect of the drug by the solution intercalation technique and emulsification cross-linking techniques. Methods: First, OFL/MMT hybrids were prepared through the solution intercalation technique. Then, OFL/MMT-intercalated OFL/MMT/CTS nanocomposite microspheres were obtained through emulsification cross-linking technology. The intercalated nanocomposite was confirmed by Fourier-transform infrared spectroscopy and X-ray diffraction. Finally, in vitro release of OFL from the microspheres was performed in simulated gastric fluids and simulated intestinal fluids. The effect of MMT content on drug encapsulation efficiency and the drug release of the nanocomposite microspheres were investigated. Results: The results showed that the release rate of OFL from the nanocomposite microspheres at pH 7.4 was higher than that at pH 1.2. Compared with pure CTS microspheres, the incorporation of certain amount of MMT in the nanocomposite microspheres can enhance the drug encapsulation efficiency and reduce the burst release. Conclusion: A sustained release particulate system can be obtained by incorporating MMT into the nanocomposite microspheres and can improve the burst release effect of the drug. |
| 学科主题 | 药物释放 |
| 收录类别 | SCI |
| 资助信息 | 中科院院长奖获得者科研启动专项(2008-06) |
| 语种 | 英语 |
| 公开日期 | 2012-09-02 |
| 源URL | [http://210.77.64.217/handle/362003/128]  |
| 专题 | 兰州化学物理研究所_环境材料与生态化学研究发展中心 |
| 推荐引用方式 GB/T 7714 | Wang AQ. A pH sensitive nanocomposite microsphere based on chitosan and montmorillonite with in vitro reduction of the burst release effect[J]. Drug Development and Industrial Pharmacy,2010,36(9):1106-1114. |
| APA | 王爱勤.(2010).A pH sensitive nanocomposite microsphere based on chitosan and montmorillonite with in vitro reduction of the burst release effect.Drug Development and Industrial Pharmacy,36(9),1106-1114. |
| MLA | 王爱勤."A pH sensitive nanocomposite microsphere based on chitosan and montmorillonite with in vitro reduction of the burst release effect".Drug Development and Industrial Pharmacy 36.9(2010):1106-1114. |
入库方式： OAI收割
来源：兰州化学物理研究所
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