Preparation and swelling properties of pH sensitive composite hydrogel beads based on chitosan-g-poly (acrylic acid)/vermiculite and sodium alginate for diclofenac controlled release
文献类型：期刊论文
| 作者 | Zhang JP(张俊平) ; Wang AQ(王爱勤); Wang Q(汪琴)
|
| 刊名 | International Journal of Biological Macromolecules
 |
| 出版日期 | 2010 |
| 卷号 | 46期号:3页码:356-362 |
| 关键词 | Composite hydrogel Bead Vermiculite pH-sensitive Controlled release |
| ISSN号 | 0141-8130 |
| 通讯作者 | 王爱勤 aqwang@licp.cas.cn |
| 中文摘要 | A series of pH-sensitive composite hydrogel beads, chitosan-g-poly (acrylic acid)/vermiculite/sodium alginate (CTS-g-PAA/VMT/SA), was prepared using CTS-g-PAA/VMT composite and SA by Ca2+ as the crosslinking agent. The structure and morphologies of the developed composite hydrogel beads were characterized by Fourier transform infrared spectroscopy and scanning electron microscopy. The swelling properties and pH-sensitivity of the beads were investigated. In addition, the drug loading and controlled release behaviors of the beads were also evaluated using diclofenac sodium (DS) as the model drug in stimulated gastric fluids (pH 2.1) and intestinal fluids (pH 6.8). The results indicate that the composite hydrogel beads showed good pH-sensitivity. The release rate of the drug from the composite hydrogel beads is remarkably slowed down, which indicated that incorporating VMT into the composite hydrogel beads can improve the burst release effect of the drug. |
| 学科主题 | 药物释放 |
| 收录类别 | SCI |
| 资助信息 | 中科院院长奖获得者科研启动专项(2008-06) |
| 语种 | 英语 |
| 公开日期 | 2012-09-02 |
| 源URL | [http://210.77.64.217/handle/362003/137]  |
| 专题 | 兰州化学物理研究所_环境材料与生态化学研究发展中心 |
| 推荐引用方式 GB/T 7714 | Zhang JP,Wang AQ,Wang Q. Preparation and swelling properties of pH sensitive composite hydrogel beads based on chitosan-g-poly (acrylic acid)/vermiculite and sodium alginate for diclofenac controlled release[J]. International Journal of Biological Macromolecules,2010,46(3):356-362. |
| APA | 张俊平,王爱勤,&汪琴.(2010).Preparation and swelling properties of pH sensitive composite hydrogel beads based on chitosan-g-poly (acrylic acid)/vermiculite and sodium alginate for diclofenac controlled release.International Journal of Biological Macromolecules,46(3),356-362. |
| MLA | 张俊平,et al."Preparation and swelling properties of pH sensitive composite hydrogel beads based on chitosan-g-poly (acrylic acid)/vermiculite and sodium alginate for diclofenac controlled release".International Journal of Biological Macromolecules 46.3(2010):356-362. |
入库方式： OAI收割
来源：兰州化学物理研究所
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