Cytotoxic sesquiterpenes and lignans from Saussurea deltoidea
文献类型：期刊论文
| 作者 | Xu, Jun-Ju1,2; Huang, Huo-Qiang1; Zeng, Guang-Zhi1; Tan, Ning-Hua1 |
| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2012-09-01 |
| 卷号 | 83期号:6页码:1125-1130 |
| 关键词 | Asteraceae Siussurea deltoidea Sesquiterpe nes Lgnans Cytotoxicity |
| ISSN号 | 0367-326X |
| 通讯作者 | Zeng, GZ (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China.,gzh_zeng@mail.kib.ac.cn ; nhtan@mail.kib.ac.cn |
| 英文摘要 | Two new sesquiterpenes deltoiden A (1) and deltoiden B (2), and two new lignans deltoignan A (9) and deltoignan B (10), together with 14 known compounds, including six sesquiterpenes 3-8 and three lignans 11-13, were isolated from the whole plant of Saussurea deltoidea. Compounds 3-8 and 11-17 were isolated for the first time from this plant. Their structures were established by spectroscopic analysis, including 2D-NMR spectroscopic techniques. Cytotoxicities of compounds 1-13 were tested against three cancer cell lines A549, Hela and SMMC-7721. Results showed that 5,6 and 7 exhibited cytotoxicity against SMMC-7721 with the IC50 values of 6.49, 9.53, 1.23 mu g/ml, 5 and 7 against A549 with the IC50 values of 4.99 and 5.35 mu g/ml, 5,6,7,13 against Hela with the IC50 values of 1.40, 4.75, 0.93 and 5.42 mu g/ml, respectively. The structure-activity relationships of sesquiterpenes 1-8 were discussed on the base of cytotoxic results. (C) 2012 Elsevier B.V. All rights reserved. |
| 类目[WOS] | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Pharmacology & Pharmacy |
| 关键词[WOS] | OCCURRING TERPENE DERIVATIVES ; CHEMICAL-CONSTITUENTS ; HEMISTEPTIA-LYRATA ; LACTONES ; GUAIANOLIDES |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China [U1032602, 31000159, 91013002, 30725048]; National New Drug Innovation Major Project of China [2011ZX09307-002-002]; National Basic Research Program of China [2009CB522300] |
| 语种 | 英语 |
| WOS记录号 | WOS:000308116600025 |
| 公开日期 | 2012-11-30 |
| 源URL | [http://ir.kib.ac.cn:8080/handle/151853/15710]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China 2.Yunnan Agr Univ, Coll Tobacco Sci, Kunming 650201, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Jun-Ju,Huang, Huo-Qiang,Zeng, Guang-Zhi,et al. Cytotoxic sesquiterpenes and lignans from Saussurea deltoidea[J]. FITOTERAPIA,2012,83(6):1125-1130. |
| APA | Xu, Jun-Ju,Huang, Huo-Qiang,Zeng, Guang-Zhi,&Tan, Ning-Hua.(2012).Cytotoxic sesquiterpenes and lignans from Saussurea deltoidea.FITOTERAPIA,83(6),1125-1130. |
| MLA | Xu, Jun-Ju,et al."Cytotoxic sesquiterpenes and lignans from Saussurea deltoidea".FITOTERAPIA 83.6(2012):1125-1130. |
入库方式： OAI收割
来源：昆明植物研究所
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