Mulberrofuran G and Isomulberrofuran G from Morus alba L.: Anti-hepatitis B Virus Activity and Mass Spectrometric Fragmentation
文献类型：期刊论文
| 作者 | Geng, Chang-An1 ; Ma, Yun-Bao1; Zhang, Xue-Mei1; Yao, Shu-Ying1; Xue, Duo-Qing1; Zhang, Rong-Ping2; Chen, Ji-Jun1
|
| 刊名 | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
 |
| 出版日期 | 2012-08-22 |
| 卷号 | 60期号:33页码:8197-8202 |
| 关键词 | Morus alba isomulberrofuran G Diels-Alder-type adducts MSn fragmentation study LCMS-IT-TOF anti-HBV activity |
| ISSN号 | 0021-8561 |
| 通讯作者 | Chen, JJ (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Yunnan, Peoples R China.,chenjj@mail.kib.ac.cn |
| 英文摘要 | Mulberrofuran G (1) and isomulberrofuran G (2), a pair of isomeric Diels-Alder-type adducts, were isolated from the root bark of Morus alba L. Isomulberrofuran G (2) as a new LIB-type Diels-Alder-type adduct, was elucidated by extensive H-1, C-13, and two-dimensional (2D) nuclear magnetic resonance (NMR) and mass spectrometry (MS) spectroscopic analyses. A fragmentation study on compounds 1 and 2 was performed by high-resolution electrospray ionization (ESI) multistage tandem mass spectrometry linked with ion-trap (IT) and time-of-flight (TOF) mass analyzers (ESI-MSn/IT-TOF) in negative mode, which resulted in obviously different fragmentations. In the MS2 experiments, the characteristic ions at m/z 451 and 439 could be revealed as their respective diagnostic ions. Mulberrofuran G (1) showed moderate activity, inhibiting hepatitis B virus (HBV) DNA replication with the IC50 value of 3.99 mu M, according to the anti-HBV assay on the HepG 2.2.15 cell line in vitro. |
| 类目[WOS] | Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology |
| 研究领域[WOS] | Agriculture ; Chemistry ; Food Science & Technology |
| 关键词[WOS] | ALDER-TYPE ADDUCTS ; 2-ARYLBENZOFURAN DERIVATIVES ; LHOU KOIDZ ; ROOT BARK ; KUWANON-P ; ION-TRAP ; TREE ; CONSTITUENTS ; PHOSPHODIESTERASE ; FLAVONOIDS |
| 收录类别 | SCI ; IC |
| 资助信息 | National Science Foundation of China for Distinguished Young Scholars [81025023] |
| 语种 | 英语 |
| WOS记录号 | WOS:000307698900017 |
| 公开日期 | 2012-11-30 |
| 源URL | [http://ir.kib.ac.cn:8080/handle/151853/15714]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Yunnan, Peoples R China 2.Kunming Med Univ, Kunming 650500, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Geng, Chang-An,Ma, Yun-Bao,Zhang, Xue-Mei,et al. Mulberrofuran G and Isomulberrofuran G from Morus alba L.: Anti-hepatitis B Virus Activity and Mass Spectrometric Fragmentation[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2012,60(33):8197-8202. |
| APA | Geng, Chang-An.,Ma, Yun-Bao.,Zhang, Xue-Mei.,Yao, Shu-Ying.,Xue, Duo-Qing.,...&Chen, Ji-Jun.(2012).Mulberrofuran G and Isomulberrofuran G from Morus alba L.: Anti-hepatitis B Virus Activity and Mass Spectrometric Fragmentation.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,60(33),8197-8202. |
| MLA | Geng, Chang-An,et al."Mulberrofuran G and Isomulberrofuran G from Morus alba L.: Anti-hepatitis B Virus Activity and Mass Spectrometric Fragmentation".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 60.33(2012):8197-8202. |
入库方式： OAI收割
来源：昆明植物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。