Chemical Constituents of Saniculiphyllum guangxiense
文献类型：期刊论文
| 作者 | Geng, Chang-An1 ; Huang, Xiao-Yan1; Lei, Li-Gong2; Zhang, Xue-Mei1; Chen, Ji-Jun1
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| 刊名 | CHEMISTRY & BIODIVERSITY
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| 出版日期 | 2012-08-01 |
| 卷号 | 9期号:8页码:1508-1516 |
| 关键词 | Saniculiphyllum guangxiense Nitrile glucosides Triterpenoids Glucosides Antiviral activity X-Ray crystallography |
| ISSN号 | 1612-1872 |
| 通讯作者 | Geng, CA (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, 132 Lanhei Rd, Heilongtan 650201, Kunming, Peoples R China.,chenjj@mail.kib.ac.cn |
| 英文摘要 | The first phytochemical investigation on Saniculiphyllum guangxiense resulted in the isolation of two new triterpenoids, 16 beta-hydroxybryodulcosigenin (3) and 3a-O-feruloylolean-12-en-27-oic acid (6), together with six known compounds, menisdaurin (1), purshianin (2), oleanolic acid (4), 3 beta-hydroxyolean-12-en-27-oic acid (5), beta-sitosterol (7), and daucosterol (8), which were characterized by extensive spectroscopic analyses and in one case by X-ray diffraction. According to this primary investigation, S. guangxiense is rich in nitrile glucosides and triterpenoids, of which menisdaurin (1; 0.06%) and purshianin (2; 0.015%) are the main constituents. Compounds 16 were assayed for their anti-hepatitis B virus (HBV) activities against the secretion of HBsAg and HBeAg, as well as HBV DNA replication on Hep G 2.2.15 cell line in vitro. The most active compound, menisdaurin (1), inhibits HBV DNA replication with an IC50 value of 0.32 mM (SI>11.97). |
| 类目[WOS] | Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Chemistry |
| 关键词[WOS] | PENTACYCLIC TRITERPENOIDS ; GLYCOSIDES |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China for Distinguished Young Scholars [81025023]; National Natural Science Foundation of China [30770152]; Major Project of Innovative Engineering [KSCX2-YW-R-181] |
| 语种 | 英语 |
| WOS记录号 | WOS:000307773700011 |
| 公开日期 | 2012-11-30 |
| 源URL | [http://ir.kib.ac.cn:8080/handle/151853/15716]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Heilongtan 650201, Kunming, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Key Lab Biodivers & Biogeog, Heilongtan 650201, Kunming, Peoples R China |
| 推荐引用方式 GB/T 7714 | Geng, Chang-An,Huang, Xiao-Yan,Lei, Li-Gong,et al. Chemical Constituents of Saniculiphyllum guangxiense[J]. CHEMISTRY & BIODIVERSITY,2012,9(8):1508-1516. |
| APA | Geng, Chang-An,Huang, Xiao-Yan,Lei, Li-Gong,Zhang, Xue-Mei,&Chen, Ji-Jun.(2012).Chemical Constituents of Saniculiphyllum guangxiense.CHEMISTRY & BIODIVERSITY,9(8),1508-1516. |
| MLA | Geng, Chang-An,et al."Chemical Constituents of Saniculiphyllum guangxiense".CHEMISTRY & BIODIVERSITY 9.8(2012):1508-1516. |
入库方式： OAI收割
来源：昆明植物研究所
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