Anti-HIV activities of extracts from Pu-erh tea
文献类型：期刊论文
| 作者 | Huang Ning1,4; Yang Liu-Meng1; Li Xiao-Li2; Zheng Chang-Bo3; Wang Rui-Rui1; Yang Yong-Ping2 ; Zheng Yong-Tang1
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| 刊名 | CHINESE JOURNAL OF NATURAL MEDICINES
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| 出版日期 | 2012-09-01 |
| 卷号 | 10期号:5页码:347-352 |
| 关键词 | Tea Camellia sinensis Pu-erh Tea Anti-HIV agents |
| ISSN号 | 1672-3651 |
| 通讯作者 | Zheng, YT (reprint author), Chinese Acad Sci, Kunming Inst Zool, Chinese Acad Sci & Yunnan Prov, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Peoples R China.,zhengyt@mail.kiz.ac.cn |
| 英文摘要 | AIM: To evaluate the anti-HIV activities of extracts from two commonly forms of Pu-erh tea (fermented), green tea-like (unfermented). METHODS: The cytotoxicities of extracts on C8166, MT4 and PBMC were assessed by MTT and the anti-HIV activities of extracts were evaluated by syncytium reduction and p24 antigen assay. RESULTS: All extracts had low cytotoxicities with the CC50 from 120.63 to 524.95 mu g.mL(-1). All extracts can inhibit HIV-induced cytopathic effects, with EC50 various from 11.13 to 67.49 mu g.mL(-1). The WEPT's were better than EEPTs, moreover the FPT's water extracts were better than the GTLPT's especially YYP-31 with SI value 42.40. YYP-31 also inhibited HIV-1(RF) and HIV-2(CBL-20) infection with EC50 of 30.82 and 39.79 mu g.mL(-1), respectively. YYP-31 reduced p24 antigen expression in HIV-1(IIIB) acute infected C8166 and in HIV-1(KM018) infected PBMC with EC50 values of 14.95 and 74.63 mu g.mL(-1), respectively. YYP-31 blocked the fusion between normal C8166 cells and HIV-1 chronically infected H9 cells with EC50 values of 234.27 mu g.mL(-1). It exhibits markedly synergistic anti-HIV activity in combination with AZT but can't inhibit activities of reverse transcriptase. CONCLUSION: Pu-erh tea extracts exhibit highly efficient anti-HIV-1 activity and can be considered to be used to as a complementary therapy or a health product to HIV patients. |
| 类目[WOS] | Integrative & Complementary Medicine ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Integrative & Complementary Medicine ; Pharmacology & Pharmacy |
| 关键词[WOS] | PLANT RHUS-CHINENSIS ; GREEN TEA ; ANTI-HIV-1 ACTIVITIES ; EPIGALLOCATECHIN GALLATE ; CATECHIN DERIVATIVES ; IN-VITRO ; PROTEIN ; POLYPHENOL ; CELLS ; BLACK |
| 收录类别 | SCI |
| 资助信息 | 973 Program [2009CB522306]; Key Scientific and Technological Program of China [2009ZX09501-029, 2012ZX10001-006, 2012ZX-10001-007]; Yunnan Province Science and Technology Project [2007BC006, 2010GA001]; NSFC [81001462, 81102483]; CAS [KSCX1-YW-10] |
| 语种 | 英语 |
| WOS记录号 | WOS:000309035800005 |
| 公开日期 | 2012-11-30 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/15664]  |
| 专题 | 昆明植物研究所_资源植物与生物技术所级重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Zool, Chinese Acad Sci & Yunnan Prov, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Lab Ethnobot, Kunming 650204, Peoples R China 3.China Pharmaceut Univ, Sch Pharm, Nanjing 210009, Peoples R China 4.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang Ning,Yang Liu-Meng,Li Xiao-Li,et al. Anti-HIV activities of extracts from Pu-erh tea[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2012,10(5):347-352. |
| APA | Huang Ning.,Yang Liu-Meng.,Li Xiao-Li.,Zheng Chang-Bo.,Wang Rui-Rui.,...&Zheng Yong-Tang.(2012).Anti-HIV activities of extracts from Pu-erh tea.CHINESE JOURNAL OF NATURAL MEDICINES,10(5),347-352. |
| MLA | Huang Ning,et al."Anti-HIV activities of extracts from Pu-erh tea".CHINESE JOURNAL OF NATURAL MEDICINES 10.5(2012):347-352. |
入库方式： OAI收割
来源：昆明植物研究所
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