The oxidation metabolites of endomorphin 1 and its fragments induced by free radicals
文献类型：期刊论文
| 作者 | Gong P(龚频) ; Chen FX(陈福欣) ; Zhao QY(赵乾宇) ; Ma GF(马国芬) ; Wang R(王锐) |
| 刊名 | Journal of Peptide Science
 |
| 出版日期 | 2009 |
| 卷号 | 15页码:337-344 |
| 关键词 | endomorphin 1 ROS EM1–melanin oxidative metabolite |
| ISSN号 | 1075-2617 |
| 通讯作者 | 王锐 |
| 中文摘要 | Endomorphin 1 (EM1), an endogenous μ-opioid receptor agonist, acts as a free radical scavenger in vitro and an antioxidant in vivo. The modification of EM1 by ROS and the properties of the OM attracted our attention. In vitro assays were performed via RP-HPLC, spectrophotometric measurements, EPR and amino acid analysis, Schmorl’s reaction to define the formation of melanin-like compounds transformed from EM1, collectively namedEM1–melanin and by solubility assay, radioligand-binding assay, NADH oxidation, superoxide anion scavenging assay to study some physical and chemical properties of EM1–melanin. Possible pathways of the formation of EM1–melanin were proposed. |
| 学科主题 | 物理化学 |
| 收录类别 | SCI |
| 资助信息 | the National Natural Science Foundation of China (Nos. 20525206;20621091;20772052);the Specialized Research Fund for the Doctoral Program in Higher Education Institutions of the Ministry of Education of China |
| 语种 | 英语 |
| WOS记录号 | WOS:000265419700002 |
| 公开日期 | 2012-12-03 |
| 源URL | [http://210.77.64.217/handle/362003/2310]  |
| 专题 | 兰州化学物理研究所_OSSO国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Gong P,Chen FX,Zhao QY,et al. The oxidation metabolites of endomorphin 1 and its fragments induced by free radicals[J]. Journal of Peptide Science,2009,15:337-344. |
| APA | 龚频,陈福欣,赵乾宇,马国芬,&王锐.(2009).The oxidation metabolites of endomorphin 1 and its fragments induced by free radicals.Journal of Peptide Science,15,337-344. |
| MLA | 龚频,et al."The oxidation metabolites of endomorphin 1 and its fragments induced by free radicals".Journal of Peptide Science 15(2009):337-344. |
入库方式： OAI收割
来源：兰州化学物理研究所
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