Bioassay-guided isolation of vasorelaxant compounds from Ziziphora clinopodioides Lam. (Lamiaceae)
文献类型：期刊论文
| 作者 | Senejoux Francois; Demougeot Celine; Kerram Parhat; Aisa Haji Akber; Berthelot Alain; Bevalot Francoise; Girard-Thernier Corine |
| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2012 |
| 卷号 | 83期号:2页码:377-382 |
| 关键词 | Uighur traditional medicine Ziziphora clinopodioides Lam. Bioassay-guided fractionation Rat aortic rings Vasorelaxant Phenolic compounds |
| ISSN号 | 0367-326X |
| 英文摘要 | Ziziphora clinopodioides Lam. (Lamiaceae) is traditionally used in Uighur's medicine for the treatment of hypertension. Our study determined and evaluated the bioactive compounds by performing an activity-guided fractionation of a hydroalcoholic extract of the whole plant, using an in vitro model of rat isolated thoracic aortic rings. Seven compounds were identified as active principles: acacetin, apigenin, chrysin, thymonin, acetovanillone, 4-hydroxyacetophenone and ethyl 4-coumarate. Apigenin, chrysin and ethyl 4-coumarate were found to be the most effective. Our results provide the first evidence that the vasodilation induced by Z. clinopodioides Lam. is mediated, at least in part, by phenolic components. |
| 学科主题 | Pharmacology & Pharmacy |
| 收录类别 | SCI |
| WOS记录号 | WOS:000300817000020 |
| 公开日期 | 2012-11-29 |
| 源URL | [http://ir.xjipc.cas.cn/handle/365002/1637]  |
| 专题 | 新疆理化技术研究所_省部共建新疆特有药用资源利用重点实验室 |
| 作者单位 | Univ Franche Comte, EA 4267, UFR Sci Med & Pharmaceut, F-25030 Besancon, France;Xinjiang Med Univ, Urumqi, Xinjiang, France;Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Xinjiang Key Lab Plant Resources & Nat Prod Chem, Urumqi 830011, Peoples R China |
| 推荐引用方式 GB/T 7714 | Senejoux Francois,Demougeot Celine,Kerram Parhat,et al. Bioassay-guided isolation of vasorelaxant compounds from Ziziphora clinopodioides Lam. (Lamiaceae)[J]. FITOTERAPIA,2012,83(2):377-382. |
| APA | Senejoux Francois.,Demougeot Celine.,Kerram Parhat.,Aisa Haji Akber.,Berthelot Alain.,...&Girard-Thernier Corine.(2012).Bioassay-guided isolation of vasorelaxant compounds from Ziziphora clinopodioides Lam. (Lamiaceae).FITOTERAPIA,83(2),377-382. |
| MLA | Senejoux Francois,et al."Bioassay-guided isolation of vasorelaxant compounds from Ziziphora clinopodioides Lam. (Lamiaceae)".FITOTERAPIA 83.2(2012):377-382. |
入库方式： OAI收割
来源：新疆理化技术研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。