protective effects of tripterygium glycoside-loaded solid lipid nanoparticles on male reproductive toxicity in rats
文献类型：期刊论文
| 作者 | Xue Mei; Jiang Zhen-Zhou; Wu Tao; Tan Ming; Liu Ji-Ping; Mu Xian-Min; Su Yu-Wen; Zhang Lu-Yong |
| 刊名 | ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
 |
| 出版日期 | 2011 |
| 卷号 | 61期号:10页码:571-576 |
| ISSN号 | 0004-4172 |
| 关键词 | Computer-assisted sperm analysis Rats, male reproductive toxicity Solid lipid nanoparticles Testis Tripterygium glycoside |
| 英文摘要 | The protective effects of tripterygium glycoside-loaded solid lipid nanoparticles (TG-SLNs) on male reproductive toxicity were investigated in rats. Thirty-six male Sprague-Dawley rats were randomly divided into three groups of 12: control group, tripterygium glycoside (TG) group, and TG-SLN group. After the animals had been orally administered with the substances for 28 consecutive days, their sperm count and sperm motility, organ coefficients, serum testosterone levels, testicular ultrastructure, and reproductive ability were observed. The results showed that the sperm motility rate in the TG group was only 3%, whereas the rates in the TG-SLN and control groups were 33 % and 71%, respectively. Compared with those in the control group, the motion counts of path velocity, track speed, progressive velocity, straightness, linearity, beat cross frequency, amplitude of lateral head displacement, and sperm concentrations in the TG-SLN group were not significantly different while those in the TG group significantly decreased (p < 0.01). TG-SLNs did not cause testicular atrophy and instead maintained normal serum testosterone levels. The effect of TG-SLNs on the testicular ultrastructure was very evident; the morphologies of Sertoli, spermatogonial, mitochondrial, and sperm cells were normal. In terms of reproductive ability, one rat (17%) from the TG-SLN group and five rats (83%) from the control group became pregnant, whereas none of the rats from the TG group became pregnant. These data indicate that TG-SLNs have potentially protective effects on male reproductive toxicity in rats. |
| 学科主题 | Pharmacology & Pharmacy ; Chemistry |
| 收录类别 | SCI |
| WOS记录号 | WOS:000296406500004 |
| 公开日期 | 2012-11-29 |
| 源URL | [http://ir.xjipc.cas.cn/handle/365002/1677]  |
| 专题 | 新疆理化技术研究所_资源化学研究室 |
| 作者单位 | China Pharmaceut Univ, Jiangsu Ctr Drug Screening Lab, Nanjing 210009, Jiangsu Provinc, Peoples R China;China Pharmaceut Univ, Key Lab Drug Qual Control & Pharmacovigilance, Nanjing 210009, Jiangsu Provinc, Peoples R China;Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Xinjiang Key Lab Plant Resources & Nat Prod Chem, Urumqi, Peoples R China;Shanxi Univ Chinese Med, Dept Pharmacol, Xianyang, Shanxi Province, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xue Mei,Jiang Zhen-Zhou,Wu Tao,et al. protective effects of tripterygium glycoside-loaded solid lipid nanoparticles on male reproductive toxicity in rats[J]. ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH,2011,61(10):571-576. |
| APA | Xue Mei.,Jiang Zhen-Zhou.,Wu Tao.,Tan Ming.,Liu Ji-Ping.,...&Zhang Lu-Yong.(2011).protective effects of tripterygium glycoside-loaded solid lipid nanoparticles on male reproductive toxicity in rats.ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH,61(10),571-576. |
| MLA | Xue Mei,et al."protective effects of tripterygium glycoside-loaded solid lipid nanoparticles on male reproductive toxicity in rats".ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH 61.10(2011):571-576. |
入库方式： OAI收割
来源：新疆理化技术研究所
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