synthesis of rupestonic acid benzyl ester derivatives and in vitro anti influenza virus and herpes simplex type i and ii viruses
文献类型：期刊论文
| 作者 | Yong Jianping; Aisa Haji Akber; Nie Lifei |
| 刊名 | CHINESE JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2009 |
| 卷号 | 29期号:10页码:1640-1644 |
| 关键词 | synthesis rupestonic acid ester derivative influenza virus herpes simplex virus biological activity |
| ISSN号 | 0253-2786 |
| 英文摘要 | To improve rupestonic acid biological activities, ten rupestonic acid benzyl ester derivatives were synthesized in the presence of DCC/DMAP with the rupestonic acid and substituted benzyl alcohol as starting materials. The synthesized compounds 2a similar to 2j were confirmed by the methods of IR, (1)H NMR, ESI-MS and preliminarily assayed in vitro against influenza viruses A3, B and herpes simplex virus I (HSV-I), herpes simplex virus II (HSV-II). The results showed that most of the synthesized compounds had distinct inhibition against influenza viruses, 2e exhibited in vitro inhibitory activity against both influenza A3 and B viruses with IC(50) values of 5.5, 5.5 mu mol/L, respectively, and 2i showed higher activity against influenza A virus with an IC(50) value of 7.8 mu mol/L. Therefore, compounds 2e, 2i can be as lead compounds for anti-flu agent. Most of the compounds showed higher inhibition against HSV-I and HSV-II viruses at 0.1 mu g/mL concentration. |
| 学科主题 | Chemistry |
| 收录类别 | SCI |
| WOS记录号 | WOS:000271694600022 |
| 公开日期 | 2012-11-29 |
| 源URL | [http://ir.xjipc.cas.cn/handle/365002/1875]  |
| 专题 | 新疆理化技术研究所_省部共建新疆特有药用资源利用重点实验室 |
| 作者单位 | Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Nat Prod Chem, Urumqi 830011, Peoples R China;Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yong Jianping,Aisa Haji Akber,Nie Lifei. synthesis of rupestonic acid benzyl ester derivatives and in vitro anti influenza virus and herpes simplex type i and ii viruses[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2009,29(10):1640-1644. |
| APA | Yong Jianping,Aisa Haji Akber,&Nie Lifei.(2009).synthesis of rupestonic acid benzyl ester derivatives and in vitro anti influenza virus and herpes simplex type i and ii viruses.CHINESE JOURNAL OF ORGANIC CHEMISTRY,29(10),1640-1644. |
| MLA | Yong Jianping,et al."synthesis of rupestonic acid benzyl ester derivatives and in vitro anti influenza virus and herpes simplex type i and ii viruses".CHINESE JOURNAL OF ORGANIC CHEMISTRY 29.10(2009):1640-1644. |
入库方式： OAI收割
来源：新疆理化技术研究所
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