Synthesis of (5R,8R)-2-(3,8-Dimethyl-2-oxo-1,2,4,5,6,7,8,8 alpha-octahydroazulen-5-yl) Acrylic Acid (Rupestonic Acid) Amide Derivatives and in vitro Inhibitive Activities against Influenza A(3),B and Herpes Simplex Type 1 and 2 Virus
文献类型：期刊论文
| 作者 | Yong Jian-ping; Lv Qiao-ying; Aisa Haji Akber; Aisa, HA
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| 刊名 | BULLETIN OF THE KOREAN CHEMICAL SOCIETY
 |
| 出版日期 | 2009 |
| 卷号 | 30期号:2页码:435-440 |
| 关键词 | Synthesis Rupestonic acid amide derivative Anti-viral activities |
| ISSN号 | 0253-2964 |
| 通讯作者 | Aisa, HA |
| 英文摘要 | 19 Aromatic ring and L-amino acid ester contained rupestonic acid amide derivatives 2a similar to 21, 3a similar to 3g were syntliesized and preliminarily evaluated in vitro against influenza virus A(3),B and herpes simplex virus type 1 (HSV-1), 2(HSV-2) by the national center for drug screening of China. The rusults showed that 2i possessed the highest inhibition against both influenza virus A(3)(TC50 = 120.6 mu mol/L, IC50 = 19.2 mu mol/L, SI = 6.3) and B(TC50 = 120.6 mu mol/L, IC50 = 29.9 mu mol/L, SI = 4.0); 2g was more active against influenza A(3) virus at very low cytotoxicity (TC50 > 2092.1 mu mol/L, IC50 = 143.7 mu mol/L, SI > 14.6) than the parent compound; Compounds 2b, 2c, 2f showed higher activities both against HSV-1 and HSV-2 than that of the parent compound, and 2f was the most potent inhibitor of HSV-1 (TC50 = 200.0 mu mol/L, IC50 = 11.3 mu mol/L, SI = 17.7) and HSV-2 (TC50 = 200.0 mu mol/L, IC50 = 20.7 mu mol/L, SI = 9.7). |
| 学科主题 | Chemistry |
| 收录类别 | SCI |
| WOS记录号 | WOS:000264903700033 |
| 公开日期 | 2012-11-29 |
| 源URL | [http://ir.xjipc.cas.cn/handle/365002/1888]  |
| 专题 | 新疆理化技术研究所_省部共建新疆特有药用资源利用重点实验室 |
| 通讯作者 | Aisa, HA |
| 作者单位 | Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Nat Prod Chem, Urumqi 830011, Peoples R China;Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yong Jian-ping,Lv Qiao-ying,Aisa Haji Akber,et al. Synthesis of (5R,8R)-2-(3,8-Dimethyl-2-oxo-1,2,4,5,6,7,8,8 alpha-octahydroazulen-5-yl) Acrylic Acid (Rupestonic Acid) Amide Derivatives and in vitro Inhibitive Activities against Influenza A(3),B and Herpes Simplex Type 1 and 2 Virus[J]. BULLETIN OF THE KOREAN CHEMICAL SOCIETY,2009,30(2):435-440. |
| APA | Yong Jian-ping,Lv Qiao-ying,Aisa Haji Akber,&Aisa, HA.(2009).Synthesis of (5R,8R)-2-(3,8-Dimethyl-2-oxo-1,2,4,5,6,7,8,8 alpha-octahydroazulen-5-yl) Acrylic Acid (Rupestonic Acid) Amide Derivatives and in vitro Inhibitive Activities against Influenza A(3),B and Herpes Simplex Type 1 and 2 Virus.BULLETIN OF THE KOREAN CHEMICAL SOCIETY,30(2),435-440. |
| MLA | Yong Jian-ping,et al."Synthesis of (5R,8R)-2-(3,8-Dimethyl-2-oxo-1,2,4,5,6,7,8,8 alpha-octahydroazulen-5-yl) Acrylic Acid (Rupestonic Acid) Amide Derivatives and in vitro Inhibitive Activities against Influenza A(3),B and Herpes Simplex Type 1 and 2 Virus".BULLETIN OF THE KOREAN CHEMICAL SOCIETY 30.2(2009):435-440. |
入库方式： OAI收割
来源：新疆理化技术研究所
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