中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Synthesis of (5R,8R)-2-(3,8-Dimethyl-2-oxo-1,2,4,5,6,7,8,8 alpha-octahydroazulen-5-yl) Acrylic Acid (Rupestonic Acid) Amide Derivatives and in vitro Inhibitive Activities against Influenza A(3),B and Herpes Simplex Type 1 and 2 Virus

文献类型:期刊论文

作者Yong Jian-ping; Lv Qiao-ying; Aisa Haji Akber; Aisa, HA
刊名BULLETIN OF THE KOREAN CHEMICAL SOCIETY
出版日期2009
卷号30期号:2页码:435-440
关键词Synthesis Rupestonic acid amide derivative Anti-viral activities
ISSN号0253-2964
通讯作者Aisa, HA
英文摘要19 Aromatic ring and L-amino acid ester contained rupestonic acid amide derivatives 2a similar to 21, 3a similar to 3g were syntliesized and preliminarily evaluated in vitro against influenza virus A(3),B and herpes simplex virus type 1 (HSV-1), 2(HSV-2) by the national center for drug screening of China. The rusults showed that 2i possessed the highest inhibition against both influenza virus A(3)(TC50 = 120.6 mu mol/L, IC50 = 19.2 mu mol/L, SI = 6.3) and B(TC50 = 120.6 mu mol/L, IC50 = 29.9 mu mol/L, SI = 4.0); 2g was more active against influenza A(3) virus at very low cytotoxicity (TC50 > 2092.1 mu mol/L, IC50 = 143.7 mu mol/L, SI > 14.6) than the parent compound; Compounds 2b, 2c, 2f showed higher activities both against HSV-1 and HSV-2 than that of the parent compound, and 2f was the most potent inhibitor of HSV-1 (TC50 = 200.0 mu mol/L, IC50 = 11.3 mu mol/L, SI = 17.7) and HSV-2 (TC50 = 200.0 mu mol/L, IC50 = 20.7 mu mol/L, SI = 9.7).
学科主题Chemistry
收录类别SCI
WOS记录号WOS:000264903700033
公开日期2012-11-29
源URL[http://ir.xjipc.cas.cn/handle/365002/1888]  
专题新疆理化技术研究所_省部共建新疆特有药用资源利用重点实验室
通讯作者Aisa, HA
作者单位Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Nat Prod Chem, Urumqi 830011, Peoples R China;Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式
GB/T 7714
Yong Jian-ping,Lv Qiao-ying,Aisa Haji Akber,et al. Synthesis of (5R,8R)-2-(3,8-Dimethyl-2-oxo-1,2,4,5,6,7,8,8 alpha-octahydroazulen-5-yl) Acrylic Acid (Rupestonic Acid) Amide Derivatives and in vitro Inhibitive Activities against Influenza A(3),B and Herpes Simplex Type 1 and 2 Virus[J]. BULLETIN OF THE KOREAN CHEMICAL SOCIETY,2009,30(2):435-440.
APA Yong Jian-ping,Lv Qiao-ying,Aisa Haji Akber,&Aisa, HA.(2009).Synthesis of (5R,8R)-2-(3,8-Dimethyl-2-oxo-1,2,4,5,6,7,8,8 alpha-octahydroazulen-5-yl) Acrylic Acid (Rupestonic Acid) Amide Derivatives and in vitro Inhibitive Activities against Influenza A(3),B and Herpes Simplex Type 1 and 2 Virus.BULLETIN OF THE KOREAN CHEMICAL SOCIETY,30(2),435-440.
MLA Yong Jian-ping,et al."Synthesis of (5R,8R)-2-(3,8-Dimethyl-2-oxo-1,2,4,5,6,7,8,8 alpha-octahydroazulen-5-yl) Acrylic Acid (Rupestonic Acid) Amide Derivatives and in vitro Inhibitive Activities against Influenza A(3),B and Herpes Simplex Type 1 and 2 Virus".BULLETIN OF THE KOREAN CHEMICAL SOCIETY 30.2(2009):435-440.

入库方式: OAI收割

来源:新疆理化技术研究所

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